Full Description
The last Kindling Conference was organized by Dr. Juhn Wada and held at the Univer sity of British Columbia, Vancouver, B. C. , in 1989. In the intervening years, research on kin dling has proceeded at an explosive pace and significant advances have been made in our understanding of the molecular biological, anatomical, and physiological substrates of kin dling, as well as in our appreciation of the age-dependent effects and complex behavioral consequences of kindling, its sensitivity to drugs, and its relevance to the clinical epilepsies. In order to review these developments and to provide researchers with an opportunity to in teract face to face and discuss the issues that preoccupy us all, we organized the Fifth Interna tional Conference on Kindling, in Victoria, B. C. , in the summer of 1996. Most of the stalwarts in kindling research were invited, as were a number of investigators whose research on kindling has become prominent in the past few years. We continue to miss the late Graham Goddard, the discoverer of kindling, and were saddened by the recent death of Eric Lothman, a prolific researcher and clinician who would have been a prominent participant. We were deeply disturbed to learn of the death of Frank Morrell, one of the earliest kindlers and an eminent neurologist, who died several months after our conference.
Contents
1. Genetic Predisposition and Kindling Susceptibility in Primates.- Developmental Patterns.- 2. Idiosyncrasies of Limbic Kindling in Developing Rats.- 3. Long-Term Effects of Kindling on Learning and Memory in the Developing Brain.- 4. Short Interval Electrical Amygdala Kindling in Infant Rats: The Paradigm and Its Application to the Study of Age-Specific Convulsants.- 5. Ontogeny of Temporal Lobe Epilepsy in Amygdala-Kindled Kittens: Phenomenology, Treatment Alternatives, and Basic Mechanisms of Sleep-Waking State Seizure Activity.- Electrophysiological Mechanisms.- 6. Lasting Prolongation of NMDA Channel Openings after Kindling.- 7. Long-Lasting Changes in the Pharmacology and Electrophysiology of Amino Acid Receptors in Amygdala Kindled Neurons.- 8. Role of the Dentate Gyms in the Spread of Seizures within the Hippocampal-Parahippocampal Circuit.- 9. Quenching: Persistent Alterations in Seizure and Afterdischarge Threshold following Low-Frequency Stimulation.- 10. Kindling-like Effects of Electroconvulsive Shock Seizures.- Morphological and Anatomical Mechanisms.- 11. The Role of Rhinencephalic Networks in Early Stage Kindling.- 12. The Role of Rhinencephalic Networks in the Late Stages of Kindling.- 13. The Perirhinal Cortex and Kindled Motor Seizures.- 14. Comparison of Synapse Remodeling following Hippocampal Kindling and Long-Term Potentiation.- 15. Neuronal Growth and Neuronal Loss in Kindling Epileptogenesis.- 16. Dissociations between Kindling and Mossy Fiber Sprouting.- Synaptic Pharmacology and Neurochemistry of Kindling.- 17. Regional Specific Changes in Glutamate and GabaA Receptors, PKC Isozymes, and Ionic Channels in Kindling Epileptogenesis of the Hippocampus of the Rat.- 18. Kindling: A Pathologic Activity-Driven Structural and Functional Plasticity inMature Brain.- 19. Activities of Protein Kinase C in the Kindling Model of Epilepsy.- 20. Kindling Induces Long-Term Changes in Gene Expression.- 21. Kindling in Genetically Altered Mice: Implications for the Role of LTP in Kindling.- 22. Neurotrophins and Kindling Epileptogenesis.- 23. Somatostatin-and Neuropeptide Y-Mediated Neurotransmission in Kindling Epileptogenesis.- Behavioral Effects of Kindling.- 24. Amygdala Kindling and Rodent Anxiety.- 25. Long-Term Amygdala Kindling and Defensive Behavior in Rats.- 26. The Neurobehavioral Consequences of Kindling.- 27. Kindling and Spatial Cognition.- 28. Long-Lasting Behavioral and Electrophysiological Effects Induced by Partial Hippocampal Kindling.- Drugs and Kindling.- 29. Protective Effects of Brain-Derived Neurotrophic Factor in Hippocampal Kindling.- 30. Perforant Path Kindling, NMDA Antagonism, and Late Paired Pulse Depression.- 31. Pharmacology of Glutamate Receptor Antagonists in the Kindling Model.- 32. Interactions between Convulsants at Low-Dose and Phenobarbital in the Hippocampal Slice Preparation.- Clinical Implications of Kindling.- 33. The Syndrome of Mesial Temporal Lobe Epilepsy: A Role for Kindling.- 34. Contributions of Kindling to Clinical Epileptology.- 35. Vagus Nerve Stimulation: Effects on Circadian Sleep Organization and Kindling Development in the Cat.- 36. Facilitation of Kindling and Long Term Potentiation by Hippocampal Lesions.- Participants Photo.
