Full Description
'nle NATO Advanced studies Institute series "Targeting of Drugs" was originated in 1981. It is now a major international forum, held every two years in cape Sounion, Greece, in which the present and the future of this important area of research in drug delivery is discussed in great depth. Five previous ASIs of the series dealt with drug carriers of natural and synthetic origin, their interaction with the biological milieu, with ways by which the latter influences such interaction and strategies by which milieu interference curtailing the ftmction of drug carriers is circumvented or relieved. 'nle present book contains the proceedings of the 6th NATO ASI "Targeting of Drugs: 'nle nias who, as chairperson of the Local Corrmittee, contriruted to the success of the Institute. 'nle ASI was held under the sponsorship of NATO Scientific Affairs Division and co-sponsored and generously financed by SmithKline Beecham Phannaceuticals (King of Prussia). Financial assistance was also provided by Syntex Laboratories Inc. (Palo Alto), Syntex Research (Palo Alto) and pfizer Central Research (Sandwich).
Contents
The Use of Derivatives of ?-MSH for Targeting to Melanomas In Vivo.- The Development of Ricin A-Chain Bnmunotoxins for Clinical Trials in Patients with Hodgkin's Disease.- Ribosome-Inactivating Proteins from Saponaria Officinalis: Tools in the Design of Immunotoxins and Ligand Toxins.- Targeting with IgG and Inmunoliposomes to Circulating Cells: The 'Target Cell Dragging' Concept.- Liposome and Immunoliposome Mediated Delivery of Proteins and Peptides.- Sterically Stabilized Liposomes as Drug Carriers: Pharmacokinetics, Tissue Distribution and Therapeutic Effects in Tumour-Bearing Mice.- Liposomes as Immunological Adjuvants.- Targeting Proteins to Antigen-Presenting Cells and Induction of Cytokines as a Basis for Adjuvant Activity.- Oral Administration of Peptides: Bypassing a Hostile Milieu.- Oral Administration of Insulin: Imitating the Natural Pathway.- Neuropeptide-Mediated Growth of Normal and Cancer Cells: Inhibition by Broad Spectrum Antagonists.- Bacterial Vectors to Target and/or Purify Polypeptides.- Participants' Photograph.- Contributors.
