Full Description
This volume is divided into three sections. Section I deals with factors that regulate the development and maturation of T cells and B cells and lymphocyte traffic. The significance of C-kit, Bcl-6, IL-7, and Vav in the development of T and B lymphocytes is discussed. A role of lymphotoxins and VAP-I in trafficking of leucocytes is reviewed. Finally, the trafficking and homing characteristics of T cell and B cell subsets, and the regulation of these processes during the immune response, is presented.
Section II discusses various aspects of naive and memory T cell biology, including clonal expansion, reprogramming of genes including those encoding cytokines and cytotoxic granules, changes in the expression of cell surface proteins involved in cell-cell adhesion, homing of naive and memory T cells, the role of MHC and cytokines in the maintenance of naive and memory T cells, and the characterization and differentiation of virus-specific memory T cell heterogeneity in mice and humans.
Novel methods of visualization of immune cells and immune systems are reviewed in Section III.
Contents
Lymphocyte Development and Lymphocyte Traffic.- 1.Lymphocyte Development in Neonatal and Adult C-Kit-Deficient (C-KIT' ) Mice.- 2.Development of Antigen-Specific Helper T Cell Responses In Vivo: Antigen-Specific Th Cell Subsets.- 3.BCL-6 Uncouples B Lymphocyte Proliferation from Differentiation.- 4.The Role of Vav Proteins in B Cell Responses.- 5.Traffic Patterns of B Cells and Plasma Cells.- 6.Lymphocyte Traffice in Lymphoid Organ Neogenesis Differential Roles of Lta and Lta.- 7.Regulation of Spleen White Pulp Structure and Function by Lymphotoxin.- 8.Enzymatic Control of Leukocyte Traficking: Role of Vap-1.- 9.Homestatic Chemokines and the Targeting of Regional Immunity.- NaÏve and Memory T Cells.- 10.Factors Regulating NaÏve T Cells Homeostasis.- 11.IL-7, The Thymus, and NaÏve T Cells.- 12.Neonates Support "Homeostatic" Proliferation.- 13.Self-Recognition and the Regulation of Cd4+ T Cell Survival.- 14.Tcr-Independent Proliferation and Differentiation of Human Cd4+ Cell Subsets Induced by Cytokines.- 15.Regulation of Memory Cd4 T Cells: Generation, Localization and Persistence.- 16.Some Properties of T Cells in Animals.- 17.Generation and Characterization of Memory Cd4 T Cells.- 18.T Cell Proliferation, Differentiation, and Restoration in Lymphopenic Individuals: For Contributed Volumes.- 19.Migration of Primary and Memory Cd8 T Cells.- 20. Cytokines and Memory-Phenotype Cd8+ Cells.- 21.Antiviral Memory T Cell Responses: Correlation With Protective Immunity and Implication for Vaccine Development.- 22.Homeostatic Proliferation But Not the Generation of Virus Specific Memory Cd8 T Cells is Impaired in the Absence of Il-15 Or IL-15RRa,.- 23.Irreversible Marking of Dendritic Cells in Vivo: for Contributed Volumes 177 Sanjay Garg.- 24.Tracking Arterial SmoothMuscle Specific T Cells in the Inflamed Vasculature.- 25.Regulation of T Cell Migration Through Formation of Immunological Synapses: The Stop Signal Hypothesis.- 26.Two-Photon Imaging in Intact Lymphoid Tissue.
