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Full Description
In the past five years significant progress has been made in our basic and clinical under standing of Parkinson's disease. The discovery that MPTP, a relatively simple molecule, is able to induce parkinsonism in otherwise healthy adult humans, and the recent interest in the possibility of "transplantation" procedures as a therapeutic modality in the treatment of Parkin son's disease have generated enormous interest in research related to Parkinson's disease. In this setting, the National Parkinson Foundation decided to organize a research meeting to bring together scientists actively engaged in research relevant to the study of Parkinson's disease, to accelerate its progress and to promote an exchange of ideas. This meeting took place in Janu ary 1988 at Key Biscayne, Florida. It was decided to publish the proceedings ofthis meeting to allow rapid documentation of the participants current findings and views regarding this rapidly of this volume follows the organization of the meeting and begins evolving field. The structure with a clinical and neuropathological review of current knowledge regarding Parkinson's dis ease. Since dopaminergic neurons playa major role in the pathophysiology of the disease, many of the contributions relate to some aspects of dopaminergic function including localiza tion, regulation, and pharmacology of dopamine receptors. A special effort has been made to provide a summary of the present knowledge of the cellular biology of the dopaminergic neurons.
Contents
1. The Current Clinical Picture of Parkinson's Disease.- 2. The Neuropathology of Parkinson's Disease.- 3. Anatomical and Pharmacological Comparisons between Dopamine D1 and D2 Receptors in Mammalian CNS.- 4. Architecture of Cholinergic Pre- and Postsynaptic Markers in the Primate Striatum.- 5. Functional Anatomy of Dopamine Receptors.- 6. New Insights into the Regulation of Dopamine Receptor Subtypes and Their Roles in Behavior.- 7. Dopamine Receptors and Signal Transduction.- 8. The Therapeutic Potential of D1 and D2 Dopamine Agonists in Parkinson's Disease.- 9. Isolation and Biochemical Characterization of the D1 and D2 Dopamine Receptors.- 10. MPTP: Twenty Questions.- 11. Search for Environment or Endogenous Neurotoxins Related to MPTP.- 12. MPTP Neurotoxicity and the "Biochemical" Blood-Brain Barrier.- 13. Biochemistry of the Neurotoxic Action of MPTP and What It May Teach Us about Etiology of Idiopathic Parkinsonism.- 14. A Biological Evaluation of Some 2'-Substituted Analogs of MPTP.- 15. Hydrogen Peroxide Production in Dopamine Neurons: Implications for Understanding Parkinson's Disease.- 16. Studies on the Toxicity of MPTP to Dopamine Neurons in Tissue and Cell Cultures.- 17. Toxicity of Structural Analogs of l-Methyl-4-phenyl Pyridinium (MPP+) and Related Compounds on Dopaminergic Neurons in Culture.- 18. Mechanisms of MPP+ Neurotoxicity: Oxyradical and Mitochondrial Inhibition Hypotheses.- 19. Plasticity of Mesencephalic Dopaminergic Neurons.- 20. Trophic Effects of Striatal Proteins on Central Dopaminergic Neurons in Culture.- 21. Age-Related Changes of Dopaminergic Functions.- 22. Adrenal Medulla Transplants in Rodents and Nonhuman Primates: Regenerative Responses in the Host Brain.- 23. Preliminary Evaluation and Report on Human AdrenalMedullary Grafting.- 24. Behavioral Performance Improves after Fetal Substantia Nigra Transplant in Bonnet Monkeys with MPTP Induced Parkinsonism.- 25. Mechanisms of Action of Substantia Nigra and Adrenal Medulla Grafts.- 26. Recent Advances in Dopaminergic Implants.- 27. Reversal of Experimental Parkinsonism in African Green Monkeys Following Fetal Dopamine Neuron Transplantation.- 28. Transplantation of Human Dopaminergic Neurons in Parkinsonism: Experimental Reality and Future Clinical Feasibility.
