Full Description
After thirty five years, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 8th Edition is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. John E. Bennett and Raphael Dolin along with new editorial team member Dr. Martin Blaser have meticulously updated this latest edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 8th Edition helps you identify and treat whatever infectious disease you see. "I highly recommend Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, together with the included ExpertConsult, the on-line version of the book that is a searchable source and is available to a variety of platforms. It is updated twice each year and is an excellent solution for health-care professionals to keep informed of the latest knowledge" Reviewed by Graefes Arch Clin Exp Ophthalmol, March 2015"..what an in depth textbook should be, a superb and vast, yet highly readable review of its topic." Reviewed by glycosmedia.com, Mar 2015"Principles and Practice of Infectious Diseases has many features and formats that make it a comprehensive, current, and clear source of information" Reviewed by Graefes Arch Clin Exp Ophthalmol, Feb 2015Get the answers to questions you have with more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than you'll find in any other infectious disease resource. Find the latest diagnoses and treatments for currently recognized and newly emerging infectious diseases, such as those caused by avian and swine influenza viruses.Put the latest knowledge to work in your practice with new or completely revised chapters on influenza (new pandemic strains); new Middle East respiratory syndrome (MERS) virus; probiotics; antibiotics for resistant bacteria; antifungal drugs; new antivirals for hepatitis B and C; Clostridium difficile treatment; sepsis; advances in HIV prevention and treatment; viral gastroenteritis; Lyme disease; Helicobacter pylori; malaria; infections in immunocompromised hosts; immunization (new vaccines and new recommendations); and microbiome.Benefit from fresh perspectives and global insights from an expanded team of international contributors.Find and grasp the information you need easily and rapidly with newly added chapter summaries. These bulleted templates include diagnosis, therapy, and prevention and are designed as a quick summary of the chapter and to enhance relevancy in search and retrieval on Expert Consult.Stay current on Expert Consult with a thorough and regularly scheduled update program that ensures access to new developments in the field, advances in therapy, and timely information.Access the information you need easily and rapidly with new succinct chapter summaries that include diagnosis, therapy, and prevention.Experience clinical scenarios with vivid clarity through a richly illustrated, full-color format that includes 1500 photographs for enhanced visual guidance.
Contents
Part I Basic Principles in the Diagnosis and Management of Infectious Diseases Section A. Microbial Pathogenesis1. A Molecular Perspective of Microbial Pathogenicity2. Microbiome of Local Sites and their Unique Biology3. Prebiotics, Probiotics and SynbioticsSection B. Host Defense MechanismsIncluding5. Adaptive Immunity: Antibodies and Immunodeficiencies 6. Mucosal Immunity7. Granulocytic Phagocytes and Deficiency States8. Complement and Deficiencies9. Human Genetics and Infection10. Nutrition, Immunity, and Infection11. Evaluation of the Patient with Suspected Immunodeficiency and Other Host Defense DefectsSection C. Epidemiology of Infectious Disease12. Epidemiologic Principles13. Emerging and Reemerging Infectious Disease Threat14. Bioterrorism: An OverviewSection D. Clinical Microbiology15. The Clinician and the Microbiology LaboratorySection E. Anti-Infective Therapy16. Principles of Anti-infective Therapy17. Molecular Mechanisms of Antibiotic Resistance in Bacteria18. Pharmacokinetics and Pharmacodynamics of Anti-infective Agents19. Penicillins20. Cephalosporins21. Other ss-Lactam Antibiotics22. Antibiotic Allergy 23. Fusidic Acid24. Aminoglycosides25. Tetracyclines and Chloramphenicol26. Rifamycins27. Metronidazole28. Macrolides, Clindamycin, and Ketolides29. Glycopeptides (Vancomycin and Teicoplanin), Streptogramins (Quinupristin-Dalfopristin), and Lipopeptides (Daptomycin)30. Polymyxins (Polymyxin B and Colistin)31. Oxazolidinones32. Sulfonamides and Trimethoprim33. Quinolones34. Unique Antibacterial Agents35. Urinary Tract Agents: Nitrofurantoin and Methenamine36. Topical Antibacterials37. Antimycobacterial Agents38. Drugs Active Against Fungi, Pneumocystis and Microsporidia39. Drugs for Malaria40. Drugs for Parasites Other Than Malaria41. Drugs for Helminths42. Antiviral Drugs General Principles 43. Antivirals Against Influenza and Other Respiratory Viruses44. Antivirals Against Herpes Viruses45. Antivirals Against Hepatitis Viruses46. Other Antiviral Drugs47. Immunomodulators48. Hyperbaric Oxygen49. Complementary and Alternative Medicines for Infectious Diseases50. Antimicrobial Management: Cost and Resistance51. Interpretation of Clinical Trials of Antimicrobial Agents52. Outpatient Parenteral Antimicrobial Therapy53. Tables of Antimicrobial Agent PharmacologyPart II Major Clinical SyndromesSection A. Fever54. Temperature Regulation and the Pathogenesis of Fever55. Fever of Unknown Origin56. The Acutely Ill Patient with Fever and RashSection B. Upper Respiratory Tract Infections57. The Common Cold58. Pharyngitis59. Acute Laryngitis60. Acute Laryngotracheobronchitis (Croup)61. Otitis Externa, Otitis Media, and Mastoiditis62. Sinusitis63. Epiglottitis64. Infections of the Oral Cavity, Neck, and HeadSection C. Pleuropulmonary and Bronchial Infections65. Acute Bronchitis66. Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, and Acute Exacerbations67. Bronchiolitis68. Acute Pneumonia69. Empyema and Pleural Effusion70. Lung Abscess71. Chronic Pneumonia72. Cystic FibrosisSection D. Urinary Tract Infections73. Urinary Tract InfectionsSection E. Sepsis74. Sepsis, Severe Sepsis, and Septic ShockSection F. Intra-Abdominal Infection75. Peritonitis and Intraperitoneal Abscesses76. Infections of the Liver and Biliary System77. Pancreatic Infections78. Splenic Abscess79. Appendicitis80. Diverticulitis and TyphlitisSection G. Cardiovascular Infections81. Endocarditis and Intravascular Infections82. Prosthetic Valve Endocarditis83. Infections of Non-Valvular Cardiovascular Devices84. Prophylaxis of Infective Endocarditis85. Myocarditis and Pericarditis86. MediastinitisSection H. Central Nervous System Infections87. Approach to the Patient with Central Nervous System Infection88. Acute Meningitis89. Chronic Meningitis90. Encephalitis, Myelitis, and Neuritis91. Brain Abscess92. Subdural Empyema, Epidural Abscess, and Intracranial Suppurative Thrombophlebitis93. Cerebrospinal fluid shunt infectionsSection I. Skin and Soft Tissue Infections94. Cellulitis, Necrotizing Fasciitis and Subcutaneous Tissue Infections95. Myositis96. Lymphadenitis and LymphangitisSection J. Gastrointestinal Infections and Food Poisoning97. Principles and Syndromes of Enteric Infection98. Esophagitis99. Nausea, Vomiting, and Noninflammatory Diarrhea100. Inflammatory Enteritides101. Enteric Fever and Other Causes of Abdominal Symptoms with Fever102. Food Poisoning 103. Tropical Sprue/EnteropathySection K. Bone and Joint Infections104. Infectious Arthritis105. Osteomyelitis106. Orthopedic Implant InfectionsSection L. Diseases of the Reproductive Organs and Sexually Transmitted Diseases107. Genital Skin and Mucous Membrane Lesions108. Urethritis109. Vulvovaginitis and Cervicitis110. Infections of the Female Pelvis111. Prostatitis, Epididymitis, and OrchitisSection M. Eye Infections112. Introduction to Ocular Infections113. Microbial Conjunctivitis114. Microbial Keratitis115. Endophthalmitis116. Infectious Causes of Uveitis117. Periocular InfectionsSection N. Hepatitis118. HepatitisSection O. Acquired Immunodeficiency Syndrome119. Global Perspectives on Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome120. Epidemiology and Prevention of Acquired Immunodeficiency Syndrome and Human Immunodeficiency Virus Infection121. Diagnosis of Human Immunodeficiency Virus Infection122. The Immunology of Human Immunodeficiency Virus Infection123. General Clinical Manifestations of Human Immunodeficiency Virus Infection (Including the Acute Retroviral Syndrome and Oral, Cutaneous, Renal, Ocular, Metabolic and Cardiac Diseases)124. Pulmonary Manifestations of Human Immunodeficiency Virus Infection125. Gastrointestinal and Hepatobiliary Manifestations of Human Immunodeficiency Virus Infection126. Neurologic Diseases Caused by Human Immunodeficiency Virus-1 and Opportunistic Infections127. Human Immunodeficiency Virus Infection in Women128. Pediatric Human Immunodeficiency Virus Infection129. Antiretroviral Therapy for Human Immunodeficiency Virus Infection130. Management of Opportunistic Infections Associated with Human Immunodeficiency Virus Infection131. Vaccines for Human Immunodeficiency Virus-1 InfectionSection P. Miscellaneous Syndromes132. Chronic Fatigue SyndromePart III Infectious Diseases and Their Etiologic AgentsSection A. Viral Diseases133. Biology of Viruses and Viral Diseases134. Orthopoxviruses: Vaccinia (Smallpox Vaccine), Variola (Smallpox), Monkeypox, and Cowpox135. Other Poxviruses That Infect Humans: Parapoxviruses, Molluscum Contagiosum, and TanapoxSection B. Herpesviridae136. Introduction to Herpesviridae137. Herpes Simplex Virus138. Chickenpox and Herpes Zoster (Varicella-Zoster Virus)139. Cytomegalovirus140. Epstein-Barr Virus (Infectious Mononucleosis)141. Human Herpesvirus Types 6 and 7142. Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus Type 8)143. Herpes B VirusSection C. Adenoviridae144. AdenovirusSection D. Papovaviridae145. Papillomaviruses146. JC, BK, and Other Polyomaviruses; Progressive Multifocal Leukoencephalopathy Hepadnaviridae147. Hepatitis B Virus and Hepatitis Delta VirusSection E. Parvoviridae148. Human Parvoviruses149. Orthoreoviruses, Orbiviruses, Coltiviruses150. Seadornaviruses (Colorado Tick Fever)151. Rotaviruses152. Alphaviruses, Including Chickungunya153. Rubella Virus (German Measles)PART IV. Flaviviruses154. Flaviviruses (Yellow Fever, Dengue, Dengue Hemorrhagic Fever, Japanese Encephalitis, West Nile Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis)155. Hepatitis CSection A. Coronaviridae156. Coronaviruses, Including Severe Acute Respiratory Syndrome (SARS)-Associated CoronavirusSection B. Paramyxoviridae157. Parainfluenza Viruses158. Mumps Virus159. Respiratory Syncytial Virus160. Human Metapneumovirus161. Measles Virus (Rubeola)162. Zoonotic Paramyxoviruses: Hendra, Nipah, and Menangle VirusesSection C. Rhabdoviridae163. Vesicular Stomatitis Virus and Related Viruses164. Rabies (Rhabdoviruses)Section D. Filoviridae165. Marburg and Ebola Virus Hemorrhagic FeversSection E. Orthomyxoviridae166. Influenza Viruses Including Avian InfluenzaSection F. Bunyaviridae167. California Encephalitis, Hantavirus Pulmonary Syndrome, and Bunyavirid Hemorrhagic FeversSection G. Arenaviridae168. Lymphocytic Choriomeningitis Virus, Lassa Virus, and the South American Hemorrhagic FeversSection H. Retroviridae169. Human T-Cell Lymphotropic Virus Types I and II170. Human Immunodeficiency VirusesSection I. Picornaviridae171. Introduction to the Enteroviruses172. Poliovirus173. Coxsackieviruses, Echoviruses, and Newer Enteroviruses174. Parechoviruses175. Hepatitis A Virus176. RhinovirusPART V. Caliciviridae and Other Gastrointestinal Viruses177. Noroviruses and Other Caliciviruses178. Astroviruses and PicobirnavirusesSection A. Unclassified Viruses179. Hepatitis E VirusSection B. Prion Diseases180. Prions and Prion Diseases of the Central Nervous System (Transmissible Neurodegenerative Diseases)Section C. Chlamydial Diseases181. Chlamydia trachomatis (Trachoma, Perinatal Infections, Lymphogranuloma Venereum, and Other Genital Infections)182. Chlamydophila (Chlamydia) Psittaci (Psittacosis)183. Chlamydia Pneumoniae184. Mycoplasma Pneumoniae and Atypical PneumoniaSection D. Mycoplasma Diseases185. Genital Mycoplasmas: Mycoplasma genitalium, Mycoplasma hominis, and Ureaplasma SpeciesSection E. Rickettsioses, Ehrlichioses, and Anaplasmosis186. Introduction to Rickettsioses, Ehrlichioses and Anaplasmosis187. Rickettsia Rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers)188. Rickettsia Akari (Rickettsialpox)189. Coxiella Burnetii (Q Fever)190. Rickettsia Prowazekii (Epidemic or Louse-Borne Typhus)191. Rickettsia typhi (Murine Typhus)192. Orientia Tsutsugamushi193. Ehrlichia Chaffeensis and Ehrlichia PhagocytophilaSection F. Bacterial Diseases194. Introduction to Bacteria and Bacterial DiseasesSection G. Gram-Positive Cocci195. Staphylococcus aureus (Including Staphylococcal Toxic Shock)196. Staphylococcus epidermidis and Other Coagulase-Negative Staphylococci197. Classification of Streptococci198. Streptococcus Pyogenes199. Nonsuppurative Poststreptococcal Sequelae: Rheumatic Fever and Glomerulonephritis200. Streptococcus pneumoniae201. Enterococcus Species, Streptococcus bovis, and Leuconostoc Species202. Streptococcus agalactiae (Group B Streptococcus)203. Viridans Streptococci, Groups C and G Streptococci, and Gemella morbillorum204. Streptococcus anginosus GroupSection H. Gram-Positive Bacilli205. Corynebacterium diphtheriae206. Corynebacteria other than Diphtheria and Rhodococcus207. Listeria Monocytogenes208. Bacillus Anthracis (Anthrax)209. Bacillus Species and Other than Bacillus anthracis210. Erysipelothrix Rhusiopathiae211. Whipple's DiseaseSection I. Gram-Negative Cocci212. Neisseria Meningitidis213. Neisseria Gonorrhoeae214. Moraxella Catarrhalis and Other Gram-Negative CocciSection J. Gram-Negative Bacilli215. Vibrio Cholerae216. Other Pathogenic Vibrios217. Campylobacter Jejuni and Related Species218. Helicobacter Pylori and Other Gastric Helicobacter Species219. Enterobacteriaceae220. Pseudomonas Species, Including Ps. Aeruginosa221. Stenotrophomonas Maltophilia and Burkholderia Cepacia Complex222. Burkholderia Pseudomallei and Burkholderia Mallei223. Acinetobacter Species224. Salmonella Species, Including Salmonella Typhi225. Shigella Species (Bacillary Dysentery)226. Haemophilus Species (Including H. Influenzae and Chancroid)227. Brucella Species228. Francisella Tularensis (Tularemia)229. Pasteurella Species230. Yersinia Species, Including Plague231. Bordetella Pertussis232. Rat-Bite Fever Streptobacillus Moniliformis and Spirillum Minus233. Legionella and Other Legionella Species234. Capnocytophaga235. Bartonella, Including Cat-Scratch Disease236. Calymmatobacterium Granulomatis (Donovanosis, Granuloma Inguinale)237. Other Gram-Negative and Gram-Variable BacilliSection K. Spirochetes238. Treponema pallidum (Syphilis)239. Endemic Treponematoses240. Leptospira Species (leptospirosis)241. Relapsing Fevers Due to Borrelia Species242. Borrelia burgdorferi (Lyme Disease, Lyme Borreliosis)Section L. Anaerobic Bacteria243. Anaerobic Infections: General Concepts244. Clostridium Difficile245. Clostridium Tetani (Tetanus)246. Clostridium Botulinum (Botulism)247. Gas Gangrene and Other Clostridium-Associated Diseases248. Bacteroides, Prevotella, Porphyromonas, and Fusobacterium Species (and Other Medically Important Anaerobic Gram-Negative Bacilli)249. Anaerobic Cocci and Anaerobic Gram-Positive Non-sporulating BacilliSection M. Mycobacterial Diseases250. Mycobacterium Tuberculosis251. Mycobacterium Leprae252. Mycobacterium Avium-Intracellulare253. Nontuberculous Mycobacteria Other Than M. Avium-Intracellulare ComplexSection N. Higher Bacterial Diseases254. Nocardia Species255. Agents of ActinomycosisSection O. Mycoses256. Introduction to Mycoses257. Candida Species258. Aspergillus Species259. Agents of Mucormycosis260. Sporothrix schenckii261. Agents of Chromomycosis262. Agents of Mycetoma263. Cryptococcus neoformans264. Histoplasma capsulatum265. Blastomyces dermatitidis266. Coccidioides Species267. Dermatophytosis and Other Superficial Mycoses268. Paracoccidioides brasiliensis269. Uncommon Fungi and Prototheca270. Pneumocystis271. MicrosporidiosisSection H. Protozoal Diseases272. Introduction to Protozoal Diseases273. Entamoeba species including amoebiasis274. Free-Living Amebas275. Plasmodium Species (Malaria)276. Leishmania Species: Visceral (Kala-Azar), Cutaneous, and Mucocutaneous Leishmaniasis277. Biology of Trypanosoma Species (American Trypanosomiasis, Chagas' Disease): Biology of Trypanosomes278. Agents of African Trypanosomiasis (Sleeping Sickness)279. Toxoplasma gondii280. Giardia lamblia281. Trichomonas vaginalis282. Babesia Species283. Cryptosporidium Species284. Isospora belli, Sarcocystis Species, Blastocystis hominis and CyclosporaSection I. Diseases Due to Toxic Algae285. Human Illness Associated with Harmful Algal BloomsJohn Glenn Morris Jr.Section J. Diseases Due to Helminths286. Introduction to Helminth Infections287. Intestinal Nematodes (Roundworms)288. Tissue Nematodes, Including Trichinosis, Dracunculiasis, and the Filariases289. Trematodes (Schistosomes and Other Flukes)290. Cestodes (Tapeworms)291. Visceral Larva Migrans and Other Unusual Helminth InfectionsSection K. Ectoparasitic Diseases292. Introduction to Ectoparasitic Diseases293. Lice (Pediculosis)294. Scabies295. Myiasis and Tungiasis296. Mites (Including Chiggers)297. Ticks (Including Tick Paralysis)Section L. Diseases of Unknown Etiology298. Kawasaki DiseasePart IV Special ProblemsSection A. Nosocominal Infections299. Organization for Infection Control and Isolation300. Disinfection, Sterilization, and Control of Hospital Waste301. Infections Caused by Percutaneous Intravascular Devices302. Nosocomial Pneumonia303. Nosocomial Urinary Tract Infections304. Nosocomial Hepatitis 305. Infections Transmitted by Transfusion and Transplantation306. Human Immunodeficiency Virus in Health Care Settings307. Nosocomial Herpesvirus InfectionsSection B. Infections in Special Hosts308. Infections in the Immunocompromised Host: General Principles309. Prophylaxis and Empirical Therapy of Infection in Cancer Patients310. Risk Factors and Approaches to Infections in Transplant Recipients311. Infections in Hematopoietic Stem Cell Transplant Recipients312. Infections in Solid Organ Transplant Recipients313. Infections in Patients with Spinal Cord Injury314. Infections in the Elderly315. Infections in Asplenic Patients316. Infections in Injection Drug Users317. Postoperative Infections and Antimicrobial ProphylaxisSection C. Surgical and Trauma-Related Infections318. Infections in Patients with Burns319. BitesSection D. Immunization320. ImmunizationSection E. Zoonoses321. ZoonosesSection F. Protection of Travelers322. Protection of Travelers323. Infections in Returning Travelers
