Full Description
In this book and atlas entitled High Density Lipoproteins, Dyslipidemia, and Coronary Heart Disease, I am indebted to the many chapter authors who have contributed their writing as well as their insights. The work grew out of a meeting on high density lipoproteins (HDLs), chaired by me and Dr. Vassilis Zannis of Boston University, and held on June 19 and 20, 2009 in Newport, Rhode Island, as a satellite meeting following the 15th International Symposium on Atherosclerosis, held in Boston. In the introduction our understanding of overall lipoprotein metabolism is reviewed, as well as the common genetic lipoprotein disorders associated with premature coronary heart disease (CHD). These familial disorders include lipoprotein(a) excess, dyslipidemia (high triglycerides and low HDL), combined hyperlipidemia (high cholesterol and high triglycerides often with low HDL), hypoalphalipoproteinemia (low HDL), and hyperc- lesterolemia. We discuss the management of these disorders. We also review other disorders including cerebrotendinous xanthomatosis, phytosterolemia, defciency of apolipoprotein B, and severe hypertriglyceridemia. The latter disorder can be associated with pancreatitus.
Thereafter, the focus is on HDL, beginning with chapters on the regulation of apolipop- tein (apo) A-I gene expression, the composition, remodeling, and the metabolism of HDL particles, as well as HDL structure, function, and its anti-infammatory properties.
Contents
to High-Density Lipoprotein, Dyslipidemia, and Coronary Heart Disease.- Regulation of ApoA-I Gene Expression and Prospects to Increase Plasma ApoA-I and HDL Levels.- High Density Lipoprotein Particles.- The Kinetics and Remodeling of HDL Particles: Lessons from Inborn Errors of Lipid Metabolism.- HDL Structure, Function, and Antiinflammatory Properties.- Human Apolipoprotein A-I Deficiency.- Human Apolipoprotein A-I Mutants.- ATP Binding Cassette A1 Transporter Function and Tangier Disease.- The Role ABCG1 in Cellular Cholesterol Efflux: Relevance to Atherosclerosis and Endothelial Function.- In Vitro Studies and Mass Flux of Cholesterol Between Serum and Macrophages.- Genetic LCAT Deficiency: Molecular Diagnosis, Plasma Lipids, and Atherosclerosis.- Human Cholesteryl Ester Transfer Protein in Human HDL Metabolism.- The HDL Receptor SR-BI.- Genetic Loci Influencing Plasma High Density Lipoprotein Cholesterol Concentrations in Humans.- Nutritional and Lifestyle Factors and High-Density Lipoprotein Metabolism.- Effects of Ethanol Intake on High Density Lipoprotein Metabolism in Humans.- Effects of Estrogen on HDL Metabolism.- Effects of Niacin on HDL Metabolism.- Effects of Statins on HDL Metabolism.- Therapeutic Regulation of High-Density Lipoprotein Transport in the Metabolic Syndrome.- Effects of Cholesterol Ester Transfer Protein Inhibition on HDL Metabolism.- HDL Infusion Therapy.- High Density Lipoproteins, Dyslipidemia, and Heart Disease: Past, Present, and Future.
