Full Description
Ischemic brain damage represents a major source of morbidity and mortality in westernized society and poses a significant financial burden on the health care system. To date, few effective therapies have been realized to treat stroke and promising avenues have not proven clinically useful. Recent evidence, however, suggests that channels, pumps, and ionic exchangers are involved in CNS ischemia and ischemic stroke, but the potential contribution of these channels for curing stroke is far less understood than for many other normal and pathological conditions. "New Strategies in Stroke Intervention: Ionic Channels, Pumps, and Transporters" analyzes the roles played by targets in stroke development and the potential action of drugs modulating these proteins. This book provides a groundbreaking review of these ionic channels, pumps, and transporters as regulators of neuronal ionic homeostasis, providing a better understanding of ischemic brain disorders and the new pharmacological avenues for a cure. It will be a useful tool for researchers working in this field, and any student interested in the physiological, pathophysiological, and pharmacological features of stroke damage.
Contents
Basis of ionic dysregulation in cerebral ischemia.- Why have ionotropic and metabotropic glutamate antagonists failed in stroke therapy?.- Mitochondrial channels as potential target for a pharmacological strategy for brain ischemia.- Endoplasmic reticulum calcium homeostasis and neuronal pathophysiology of stroke.- NCX gene product expression and function in brain ischemia.- The role of Na-K-Cl co-transporter in cerebral ischemia.- The Na(+)/H(+) exchanger: a target for therapeutic intervention in cerebral ischemia.- Na+/K+-ATPase as drug target for the treatment of ischemic stroke.- Acid-sensing ion channels (ASICs): new targets for cerebral ischemia.- TRPM7 and TRPC in ischemic CNS injury. - Subtypes of voltage-gated Ca2+ channels and ischemic brain injury.- Role of K+ channels in brain ischemia.- Clinical trials with drugs targeting ionic channels, antiporters, and pumps in ischemic stroke.- Index.
