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Full Description
Structural Glycobiology covers the experimental, theoretical, and alternative technologies used in the study of the structural basis for the diverse biological roles of carbohydrates. The book overviews the application of specialized technologies to the study of carbohydrates in biology, reviews relevant and current research in the field, and is illustrated throughout by specific examples of how research investigations have yielded key structural and associated biological data on carbohydrates and glycolipids. In particular, the book focuses on:
X-ray crystallography and small-angle scattering, NMR, and cryo-electron microscopy techniques
Theoretical (modeling-based) approaches, such as molecular mechanics, molecular dynamics, free energy calculations, and carbohydrate docking
Alternative techniques for yielding structural information on carbohydrates from complex biological samples
Carbohydrates in medicine, specifically in areas that have been directly impacted by our understanding of the structural role of carbohydrates in immune recognition: cancer, organ transplantation, and infection
Contents
Experimental Techniques to Determine Three-Dimensional Structures: Crystallography and Small-Angle Scattering of Carbohydrate-Protein Complexes and Glycoproteins. Nuclear Magnetic Resonance Studies of Carbohydrate-Protein Interactions. Electron Cryomicroscopy of Large Glycoprotein Assemblies. Theoretical/Modeling Techniques to Predict Three-Dimensional Structures: Protein-Carbohydrate Interactions: Computational Aspects. Docking of Carbohydrates into Protein Binding Sites. Alternative Approaches for Yielding Detailed Structural Information: Mass Spectrometry for Glycomics Analysis of N- and O-Linked Glycoproteins. Glycan-Based Arrays for Determining Specificity of Carbohydrate-Binding Proteins. Carbohydrates in Medicine: Structural Glycobiology: Applications in Cancer Research. Structural Glycobiology: Applications in Organ Transplantation. Structural Glycobiology: Applications in Viral Infection. Developing Drugs from Sugars Current State of Glycosaminoglycan-Derived Therapeutics.
