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Full Description
Developing better therapies for neurological conditions such as Parkinson's and Alzheimer's diseases remains an enduring problem for 21st century medicine. The testing of novel therapies will continue to require a robust experimental animal model. The marmoset is an ideal animal model for modern neurological research because of the species' convenient body size, ease of handling, and the fundamental similarity of its neuroanatomy to the human brain.
The Stereotaxic and Chemoarchitectural Atlas of the Brain of the Common Marmoset (Callithrix jacchus) is the most detailed atlas of the marmoset brain available. An essential tool for researchers developing more effective therapies for disabling and debilitating neurological disorders, the book contains:
Fully delineated, high-quality (400x magnification) images of Nissl-stained, acetylcholinesterase histochemically-stained and parvalbumin, calbindin and neurofilament immunohistochemically-stained coronal and sagittal sections, as well as structural magnetic resonance images (MRI) for direct comparisons
Line diagrams with delineations of all cortical and subcortical structures, with grid overlays so the precise position of each structure can be located stereotaxically relative to the interaural line and infraorbital margin
Quantitative data regarding volume and cell number of many of the structures delineated in the atlas, regularly updated on an accompanying website
Standard nomenclature widely used in the Paxinos group of atlases, allowing users to compare and contrast homologous nuclei in different species using the major available atlases
The book combines modern imaging (MRI) with an accurate stereotaxic and chemoarchitectonic section atlas, making the fullest use of available technologies. The downloadable resources include all the images in full color. Designed by publishing neuroanatomists, this book/downloadable resources will be a cornerstone in marmoset brain research for years to come.
Contents
Introduction: Ecology, Behavior and Evolution of the Common Marmoset, The Marmoset in Neuroscience Research. Key Features of this Book. Animals and Ethical Considerations. Methods: MRI, Perfusion and Tissue Processing. Imaging, Principles of Delineation and Abbreviation. Quantitation of Volumes and Neuronal Populations of Motor Nuclei. Bases for Delineation of Specific Regions and Nuclei. References. Named structures and abbreviations. Index of atlas plates. Atlas plates.
