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基本説明
This text combines the basic principles and theories. It contains real world applications in drug delivery systems, tissue engineering, and artifical organs. Previous ed: 2006.
Full Description
Encompassing a variety of engineering disciplines and life sciences, the very scope and breadth of biomedical engineering presents challenges to creating a concise, entry level text that effectively introduces basic concepts without getting overly specialized in subject matter or rarified in language. Basic Transport Phenomena in Biomedical Engineering, Third Edition meets and overcomes these challenges to provide the beginning student with the foundational tools and the confidence they need to apply these techniques to problems of ever greater complexity.Bringing together fundamental engineering and life science principles, this highly accessible text provides a focused coverage of key momentum and mass transport concepts in biomedical engineering. It offers a basic review of units and dimensions, material balances, and problem-solving tips, and then emphasizes those chemical and physical transport processes that have applications in the development of artificial and bioartificial organs, controlled drug delivery systems, and tissue engineering. The book also includes a discussion of thermodynamic concepts and covers topics such as body fluids, osmosis and membrane filtration, physical and flow properties of blood, solute and oxygen transport, and pharmacokinetic analysis. It concludes with the application of these principles to extracorporeal devices as well as tissue engineering and bioartificial organs.Designed for the beginning student, Basic Transport Phenomena in Biomedical Engineering, Third Edition provides a quantitative understanding of the underlying physical, chemical, and biological phenomena involved. It offers mathematical models using the `shell balance" or compartmental approaches, along with numerous examples and end-of-chapter problems based on these mathematical models and in many cases these models are compared with actual experimental data. Encouraging students to work examples with the mathematical software package of their choice, this text provides them the opportunity to explore various aspects of the solution on their own, or apply these techniques as starting points for the solution to their own problems.
Contents
IntroductionReview of Units and DimensionsDimensional Equation Tips for Solving Engineering ProblemsConservation of MassA Review of Thermodynamic ConceptsThe First Law of ThermodynamicsThe Second Law of ThermodynamicsPropertiesThe Fundamental Property RelationsSingle Phase Open SystemsPhase EquilibriumPhysical Properties of the Body Fluids and the Cell MembraneBody FluidsFluid CompositionsCapillary Plasma Protein RetentionOsmotic PressureFormation of the Interstitial FluidNet Capillary Filtration RateLymphatic SystemSolute Transport Across the Capillary EndotheliumThe Cell MembraneIon PumpsThe Physical and Flow Properties of BloodPhysical Properties of BloodCellular ComponentsRheologyRelationship Between Shear Stress and Shear RateHagan-Poiseuille EquationOther Useful Flow RelationshipsRheology of BloodThe Casson EquationUsing the Casson EquationThe Velocity Profile for Tube Flow of a Casson FluidTube Flow of Blood at Low Shear RatesThe Effect of The Diameter at High Shear RatesMarginal Zone TheoryUsing the Marginal Zone TheoryBoundary Layer TheoryGeneralized Mechanical Energy Balance EquationCapillary Rise and Capillary ActionSolute Transport in Biological SystemsDescription of Solute Transport in Biological SystemsCapillary PropertiesCapillary FlowratesSolute DiffusionSolute Transport by Capillary FiltrationSolute Diffusion Within Heterogeneous MediaSolute PermeabilityThe Irreversible Thermodynamics of Membrane TransportTransport of Solutes Across the Capillary WallTransport of Solute Between a Capillary and the Surrounding Tissue SpaceOxygen Transport in Biological SystemsThe Diffusion of Oxygen In Multicellular SystemsHemoglobinThe Hemoglobin-Oxygen Dissociation CurveOxygen Levels in BloodThe Hill EquationOther Factors That Can Affect the Oxygen Dissociation CurveTissue OxygenationOxygen Transport in Bioartificial Organs and Tissue Engineered ConstructsSteady State Oxygen Transport in a Perfusion BioreactorOxygen Transport in the Krogh Tissue CylinderAn Approximate Solution for Oxygen Transport in the Krogh Tissue Cylinder Artificial BloodPharmacokinetic AnalysisTerminologyEntry Routes for DrugsModeling ApproachesFactors that Affect Drug DistributionDrug ClearanceA Model for Intravenous Injection of DrugAccumulation of Drug in the UrineConstant Infusion of DrugFirst Order Drug Absorption and EliminationTwo Compartment ModelsExtracorporeal DevicesApplicationsContacting SchemesMembrane Solute TransportEstimating the Mass Transfer CoefficientsEstimating the Solute Diffusivity in BloodHemodialysis Blood Oxygenators Immobilized Enzyme Reactors Affinity AdsorptionTissue EngineeringIntroductionCell TransplantationThe Extracellular Matrix (ECM)Cellular InteractionsPolymeric Support StructuresBiocompatibility and the Initial Response to an ImplantTissue Ingrowth in Porous Polymeric StructuresMeasuring the Blood Flow Within Scaffolds Used for Tissue EngineeringCell Transplantation into Polymeric Support StructuresBioreactor Design for Tissue EngineeringBioartificial OrgansBackgroundSome ImmunologyImmunoisolationPermeability of Immunoisolation MembranesMembrane Sherwood Number Bioartificial OrgansThe Bioartificial LiverThe Bioartificial KidneyDesign Considerations for Bioartificial OrgansReferencesIndex
