Full Description
"Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms" will provide a timely and long lasting guide for investigators in the fields of cardiovascular physiology and pathophysiology, pulmonary vascular disease, high-altitude physiology and medicine. In addition, it provides a solid scientific foundation for subsequent applications in clinical practice. The volume is divided into eight sections: Physiology and Pathophysiology of HPV; Role of Intracellular Ca2+ and Ca2+ sensitivity in HPV- Role of Ion Channels in HPV; Role of the Endothelium in HPV; Mechanisms of Oxygen Sensing in the Pulmonary Vasculature; Oxygen-Sensing Mechanisms in other Organs and Tissues; Pathology and Mechanisms of Hypoxia; Induced Pulmonary Hypertension; and Experimental Models for the Study of HPV. State-of-the-art findings relevant to cellular and molecular processes of hypoxic pulmonary vasoconstriction as well as knowledge regarding etiological mechanisms and experimental therapeutics are well covered and complete the overview this volume provides.
Contents
Physiology and Pathophysiology of Hypoxic Pulmonary Vasoconstriction.- Physiological Function of Hypoxic Pulmonary Vasoconstriction.- Hypoxic Pulmonary Vasoconstriction: Heterogeneity.- The Physics of Hypoxic Pulmonary Hypertension and Its Connection with Gene Actions.- Role of Intra Cellular Ca2+ and Ca2+ Sensitivity in Hypoxic Pulmonary Vasoconstriction.- Ca2+ Sparks in Pulmonary Artery Smooth Muscle Cells: Implications for Hypoxic Pulmonary Vasoconstriction.- Hypoxia-Mediated Regulation of Ca2+ Transients in Pulmonary Artery Smooth Muscle Cells.- Calcium Mobilization by Hypoxia in Pulmonary Artery Smooth Muscle.- Critical Role of Ca+ Sensitization in Acute Hypoxic Pulmonary Vasoconstriction.- Role of Ion Channels in Hypoxic Pulmonary Vasoconstriction.- Regulation of Ion Channels in Pulmonary Artery Smooth Muscle Cells.- Regulation of O2-Sensitive K+ Channels by a Mitochondrial Redox Sensor: Implications for Hypoxic Pulmonary Vasoconstriction.- Hypoxic Regulation of K+ Channel Expression and Function in Pulmonary Artery Smooth Muscle Cells.- Transient Receptor Potential Channels and Capacitative Ca2+ Entry in Hypoxic Pulmonary Vasoconstriction.- Role of Endothelium in Hypoxic Pulmonary Vasoconstriction.- Endothelium-dependent Hypoxic Pulmonary Vasoconstriction.- Mechanisms of Oxygen Sensing in the Pulmonary Vasculature.- Chemistry of Oxygen and Its Derivatives in the Lung.- Interaction of Oxidants With Pulmonary Vascular Signaling Systems.- Mitochondrial Oxygen Sensing in Hypoxic Pulmonary Vasoconstriction.- Redox Oxygen Sensing in Hypoxic Pulmonary Vasoconstriction.- Mitochondrial Diversity in the Vasculature: Implications for Vascular Oxygen Sensing.- Hypoxia, Cell Metabolism, and cADPR Accumulation.- Oxygen-Sensing Mechanisms in Other Organs and Tissues.- Involvement of Intracellular Reactive Oxygen Species in the Control of Gene Expression by Oxygen.- Oxygen Sensing, Oxygen-sensitive Ion Channels and Mitochondrial Function in Arterial Chemoreceptors.- Oxygen Sensing by Adrenomedullary Chromaffin Cells.- Oxygen-sensitive Ion Channels in Pheochromocytoma (PC12) Cells.- Pathology and Mechanisms of Hypoxia-Induced Pulmonary Hypertension.- Pulmonary Vascular Remodeling in Hypoxic Pulmonary Hypertension.- Rho/Rho-kinase Signaling in Hypoxic Pulmonary Hypertension.- Hypoxia-sensitive Transcription Factors and Growth Factors.- Heterogeneity in Hypoxia-Induced Pulmonary Artery Smooth Muscle Cell Proliferation.- Persistent Pulmonary Hypertension of the Newborn: Pathophysiology and Treatment.- Roles for Vasoconstriction and Gene Expression in Hypoxia-induced Pulmonary Vascular Remodeling.- Polyamine Regulation in Hypoxic Pulmonary Arterial Cells.- Strain Differences of Hypoxia-Induced Pulmonary Hypertension.- Experimental Models for the Study of Hypoxic Pulmonary Vasoconstriction.- Animal and In Vitro Models for Studying Hypoxic Pulmonary Vasoconstriction.- Transgenic and Gene-Targeted Mouse Models in Hypoxic Pulmonary Hypertension Research.- Measurement of Ionic Currents and Intracellular Ca2+ Using Patch Clamp and Fluorescence Microscopy Techniques.
