基本説明
Includes chapters on the following: Interactions between the tumor and bone microenvironment and the development of tumor-induced osteoclastic and osteoblastic lesions; Specific effectors of bone metastasis including macrophage inflammatory protein, collagen-I, and more.
Full Description
Metastasis to bone is a common event in cancer. However, due to the skeleton's unique structure, exploring how cancer cells target the skeleton and interact with the bone microenvironment is challenging. The Biology of Skeletal Metastases covers areas that are important to both clinicians and basic scientists seeking an enhanced understanding of mechanisms of skeletal metastasis, as well as descriptions of cutting edge therapies for skeletal metastases.
Both increased efforts by many investigators and advances in research methodologies have provided a wealth of information in the area of skeletal metastases. The Biology of Skeletal Metastases brings together experts to describe these many advances. This book provides background in basic bone biology and biology of metastasis for novice investigators and highlights many advances in this challenging field for the experienced investigator.
Contents
1. The Basic Biology of Metastasis.- 2. Clinical Aspects of Bone Metastases in Prostate Cancer.- 3. Animal Models of Bone Metastasis.- 4. MIP-1 Alpha and Myeloma Bone Disease.- 5. Type I Collagen-Mediated Changes in Gene Expression and Function of Prostate Cancer Cells.- 6. PTHRP and Skeletal Metatasis.- 7. OPG, RANKL, and RANK In Cancer Metastasis: Expression and Regulation.- 8. Matrix Metalloproteinaess and Bone Metastasis.- 9. Endothelins in Bone Cancer Metastases.- 10. Bisphosphonate Actions on Bone and Visceral Metastases.- 11. Gene Therapy for Prostate Cancer Bone Metastasis.- 12. Cancer Cells Homing to Bone: The Significance of Chemotaxis and Cell Adhesion.- 13. Histological, Immunophenotypic and Histomorphometric Characterization of Prostate Cancer Bone Metastases.
