エドワード・B・ルイス主要著作集<br>Genes, Development and Cancer : The Life and Work of Edward B. Lewis (2004. 576 p.)

エドワード・B・ルイス主要著作集
Genes, Development and Cancer : The Life and Work of Edward B. Lewis (2004. 576 p.)

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  • 製本 Hardcover:ハードカバー版/ページ数 576 p.
  • 言語 ENG
  • 商品コード 9781402075919

基本説明

Nobel Prize Winner, Edward B. Lewis' key publications the fields of genetics, developmental biology, radiation and cancer are compiled within one volume.

Full Description


- For the first time, Nobel Prize winner, Edward B. Lewis' research papers are published within one volume- Papers are organized into sections that reflect the focus of the research- Commentaries by Howard Lipshitz highlight key methods and results by explaining the science so it is accessible to upper-level undergraduates, graduate students, and professional researchers

Contents

Background -Invention of the cis-trans test for position effects -Position pseudoalleles -The bithorax pseudoalleles and the concept of developmental control -Gene evolution by tandem duplication -From cisvection to transvection- Extending the bithorax pseudoallelic series -Genetic versus functional models -From genes to gene complexes -Developmental genetics -Gain-of-function and loss-of-function alleles, and the operon model -Genetic mosaics: spatial and temporal aspects of bithorax function -The 1978 paper: a paradigm for the genetic control of development -Trans-acting regulators: positive and negative control of the homeotic complexes -Cis-regulation within the BX-C: the rules of engagement -Positional cloning of the BX-C -Completing the bithorax mutant series -The molecular basis of developmental control -Bithorax and the evolution of sexually dimorphic traits -DNA sequence motifs in the cis-regulatory regions of the BX-C -Evolution of the HOX complexes -Genetic and somatic effects of ionizing radiation -The political and social context -Leukemia and ionizing radiation -Political fallout -Thyroid radiation doses from weapons fallout -Best estimates of risk: leukemia in populations exposed to low doses of radiation -Estimates of lung cancer risk: the Batelle beagles