Pituitary Adenylate Cyclase-Activating Polypeptide (Endocrine Updates, 20)

Vaudry, Hubert (EDT)/ Arimura, Akira (EDT)

Kluwer Academic Pub（2003/01発売）

• 製本 Hardcover:ハードカバー版／ページ数 406 p.
• 言語 ENG
• 商品コード 9781402073069
• DDC分類 573.86465

Full Description

Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.

Contents

1 PACAP: Discovery, Gene, Receptors.- 2 Molecular Evolution of PACAP Precursor and PACAP Receptors.- 3 Development of Selective Ligands for PACT, VPAC1 and VPAC2 Receptors.- 4 Molecular Pharmacology and Structure-Function Analysis of PACAP/VIP Receptors.- 5 PACAP Receptor Signaling.- 6 Function of PACAP in the Central Nervous System.- 7 Function of PACAP in the Hypothalamo-Pituitary Complex.- 8 PACAP in the Endocrine Pancreas.- 9 Function of PACAP in the Adrenal Cortex.- 10 PACAP: An 'Emergency Response' Co-Transmittter in the Adrenal Medulla.- 11 PACAP in the Urogenital Tract.- 12 Function of PACAP in the Cardiovascular System.- 13 Function of PACAP in the Respiratory System.- 14 Function of PACAP in the Immune System.- 15 PACAP Receptor Knockout and Transgenics. What Have We Learnt?.- 16 Consequences of PACAP Gene Knockout.- 17 The Biological Significance of PACAP and PACAP Receptors in Human Tumors: From Cell Lines to Cancers.