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Full Description
This book gathers the contributions of world-leading experts to provide a comprehensive overview of recent advances in gastro-intestinal oncology. In addition to analyzing scientific data, the book provides immediate applications for everyday clinical work. Among many developments examined are animal models for GI cancers, statistical models for predicting polyp recurrence after polypectomies, concepts for improving public awareness of GI cancers and basic science concepts poised to enter clinical use.
Contents
List of principal contributors.- List of chairpersons.- Preface.- SECTION I: OESOPHAGEAL CANCER: AETIOLOGY, SCREENING AND TREATMENT.- 1. State-of-the art lecture: Of mice and men: mouse models for colon carcinogenesis.- 2. Surgical strategies in oesophageal cancer.- 3. Neoadjuvant therapy of oesophageal carcinoma and carcinoma of the gastro-oesophageal junction.- SECTION II: GASTRIC CANCER STANDARD AND NOVEL THERAPIES.- 4. Helicobacter pylori and risk of gastric cancer and lymphoma.- APC?.- 5. State-of the -Art lecture: The Wnt pathway in tumorigenesis.- 6. Role of transforming growth factor beta and Wnt signalling pathways in colon cancer.- 7. Beyond the adenomatous polyposis coli era: alternative pathways to colorectal cancer.- 8. The molecular regulation of the malignant progression of human colorectal cancer.- SECTION IV: COLORECTAL CANCER: NEW SCREENING STRATEGIES FOR THE NEW MILLENNIUM.- 9. Impact of the national polyp study.- 10. Colorectal cancer screening cost-effectiveness and adverse events.- 11. Detecting dysplasias in ulcerative colitis.- SECTION V: COLORECTAL CANCER : PREVENTION.- 12. A statistical model for post-polypectomy surveillance: a virtual alternative to virtual colonoscopy?.- 13. Differential signalling pathways of tumour-promoting and tumour-inhibiting bile acids in colonic carcinogenesis.- SECTION VI: COLORECTAL CANCER : PREDICTIVE MARKERS - GENE PROFILING.- State-of-the-art lecture: A gene expression signature to predict recurrrence of Dukes' B colon cancer.- 15. Chromosomal deletions as predictors for recurrence of early stage colorectal cancer.- SECTION VII: COLORECTAL CANCER : INTERDISCIPLINARY TREATMENT.- 16. Resection or local abiation of colorectal cancer metastasis to the liver - pro and con.- 17. Radiation therapy for rectal cancer: neoadjuvant or adjuvant?.- Index.



