基本説明
Reprinted from "Genetica" Volume 122 (1), 2004.
Full Description
The Second Georgia Genetics Symposium was held color. Soon after, he joined the sta? of The Jackson in September 2000, and the development of this Laboratory in Bar Harbor, Maine. book took place over the nearly 4 years that ensued. Much of Bill's research at the lab was centered During this time, many advances in the Genome around investigating phenotypic variability within Project and mouse mutagenesis were made. In the highly inbred strains, and in that connection he book overview, we discuss the development of the developed the technique of ovarian transplanta- Genome Project (which is the context for the sym- tion (even using embryonic donors) and a genetic posium), the role the mouse was playing at that scheme whereby graft compatibility could be time, how that role has evolved, and how the combined with the ability to distinguish o?spring chapters of the book address issues in mouse func- from donor and regenerated host ovaries. His tional genetics. Many of the chapters in this book work was in?uenced by the second World War, will provide useful resources for years to come. ?rst because The Jackson Laboratory turned into Of greater impact, our keynote speaker, the a production colony for the military, primarily to mutagenesis pioneer William L. (Bill) Russell, produce mice for typhoid testing, and secondly, passed away on July 23, 2003.
Contents
From the Atomic Age to The Genome Project.- Chemical mutagenesis of the mouse genome: an overview.- Effects of male germ-cell stage on the frequency, nature, and spectrum of induced specific-locus mutations in the mouse.- Allelic mutations of the sodium channel SCN8A reveal multiple cellular and physiological functions.- Towards a mutant map of the mouse - new models of neurological, behavioural, deafness, bone, renal and blood disorders.- Implementing large-scale ENU mutagenesis screens in North America.- Genetic mapping and ENU mutagenesis.- The Mouse Phenome Project.- Genetically altered mice: phenotypes, no phenotypes, and Faux phenotypes.- Visualizing the laboratory mouse: capturing phenotype information.
