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基本説明
The first volume entirely dedicated to microfabricated cell-based systems.
Full Description
Dear reader, In the past few years we have observed an interesting mutual interest of two fields of research and development in each other. Life sciences area researchers discovered the opportunities offered my micro- and nanotechnology, while people from the microfluidics and BIOMEMS area discovered the application potential of these technologies in cell biology. Unfortunately, these two research communities share little in common: they read and publish in different scientific journals, have incompatible jargons, attend separate conferences, and have a different scientific approach and culture. This is most strikingly illustrated when you give a MEMS researcher some cells to experiment with, or hand over a couple of chips to a cell biologist. Or imagine explaining a microengineer different intracellular apoptotic pathway or a cell biologist about tensile stress in underetched LPCVD membranes. And yet, there is an enormous potential of combining the expertises available in these two fields. It is our goal to illustrate this potential with this book focusing on microfluidics technologies for "cellomics", research on or with cells. In our view, the field is still too immature to compile a textbook for students, and this volume is rather meant to be a collection of first class papers of leaders in this emerging field. This volume will enable researchers from both communities to get a rapid "state of the art" overview, and also to get an impression what kind of possibilities this area offers. Micro- and nanotechnologists will get inspiration about applications, life science researchers about technological capabilities.
Contents
Microfluidic devices for cellomics.- Pretreatment of biological sample for microchip analysis.- Liposomes as model cellular systems.- Versatile chip-based tool for the controlled manipulation of microparticles in biology using high Frequency Electromagnetic Fields.- Micro-electroporation in cellomics.- Patch-Clamp Microsystems.- Using lab-on-a-chip Technologies to Understand Cellular Mechanotransduction.- Analysis of Apoptosis on Chip.- On-chip single-cell cultivation systems.- Human Embryonic Stem Cells and Microfluidics.- Cellular and Subcellular Analysis on Chip.- Microfluidic Cell-Culture Devices.- Micromachined Bioreactor for in Vitro Cell Self-Assembly and 3D Tissue Formation.
