Full Description
Plasma membrane-associated channels known as gap junctions, along with their protein building blocks-connexins-have an important functional role in a range of immunological processes. This book assembles and synthesizes four decades of the most important research carried out in this field. The chapters focus on the latest progress made on translating the knowledge gained to specific treatment modalities, including approaches for reducing scarring and cardiac arrhythmia, combating inflammation in the central nervous system and enhancing epithelial tissue repair. The book will inform and update specialists, clinical practitioners and those studying the potential for commercial applications.
Contents
Immunology and Cell Biology. Communication in the Immune System by Connexin Channels. Gap Junctions and Connexins in the Hematopoietic-Immune System: Structural Considerations. Approaches for Studying the Role(s) of Gap Junctions in the Immune System. Gap Junctions in Antigen-Presenting Cells. Connect the Immune System: Roles of Gap Junctions in Antigen Presentation and T Cell Activation. Gap Junctions and Connexins in the Immune Defense against Tumors. Inflammation and Inflammatory Diseases. Connexins in Atherosclerosis. Connexins in Lung Function and Inflammation. Effect of Oxidative Stress on Connexins in the Vasculature. Regulation of Gap Junctions and Cellular Coupling within the Microvasculature in Response to Acute Inflammation. Impact of Microglial Activation on Astroglial Connexin Expression and Function in Brain Inflammation. A Role for Connexins in Inflammatory Disorders of the Epidermis. Connexin-Based Therapeutical Approaches in Inflammatory Diseases. Translating Basic Research on Cx43 Gap Junctions into Therapies for Reducing Scarring and Cardiac Arrhythmia. Connexin-Based Therapeutic Approaches to Inflammation in the Central Nervous System. Enhancing Epithelial Tissue Repair and Reducing Inflammation by Targeting Connexins. Index.
