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Full Description
Flavonoids exert a multiplicity of biological effects on humans and can have beneficial implications for numerous disease states. Flavonoids and Related Compounds: Bioavailability and Function examines current knowledge regarding the absorption, metabolism, and bioavailability of individual flavonoids and related phenolic compounds.
Profiling the latest evidence of their impact on various human pathological conditions, the book summarizes current thinking with regard to the biotransformation and conjugation of individual compounds in the gastrointestinal tract, liver, large intestine, and cells. It highlights a topic that has been largely ignored—namely the extent to which dietary phenolics components undergo metabolism in the large intestine. It also explores the generation of bacterially derived metabolites. Individual chapters discuss which metabolites enter the circulatory system and are likely to offer protective actions against human diseases.
Edited by internationally recognized leaders in the field, the book presents contributions by a panel of experts who demonstrate the potential of flavonoids in ameliorating a range of disease states, including cardiovascular disease, Alzheimer's and Parkinson's disease and other neurodegenerative disorders, and cancer. The research presented in this volume provides a reliable starting point for further inquiry and experimentation.
Contents
Bioavailability of Flavanones. Bioavailability of Dietary Monomeric and Polymeric Flavan-3-ols. Anthocyanins: Understanding Their Absorption and Metabolism. Bioavailability of Flavonols and Flavones. Bioavailability of Isoflavones in Humans. Dietary Hydroxycinnamates and Their Bioavailability. Bioavailability of Dihydrochalcones. Occurrence, Bioavailability, and Metabolism of Resveratrol. Bioavailability and Metabolism of Ellagic Acid and Ellagitannins. Colon-Derived Microbial Metabolites of Dietary Phenolic Compounds. Synthesis of Dietary Phenolic Metabolites and Isotopically Labeled Dietary Phenolics. Interactions of Flavan-3-ols Within Cellular Signaling Pathways. Flavonoids and Vascular Function. Effects of Flavonoids on the Vascular Endothelium: What Is Known and What Is Next?. Green Tea Flavan-3-ols and Their Role in Protecting Against Alzheimer's and Parkinson's Disease Pathophysiology. Flavonoids and Neuroinflammation. Effects of Flavonoids on Cognitive Performance. Flavonoids and Oral Cancer. Flavonoids and Cancer—Effects on DNA Damage. Index.
