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Full Description
Fundamentals of Biochemistry, 6th edition, with new authors Destin Heilman and Stephen Woski, provides a solid biochemical foundation that is rooted in chemistry while presenting complete and balanced coverage that is clearly written and relevant to human health and disease. This edition includes new pedagogy and enhanced visuals that better adapt the text for the modern student, including a focus on enhanced self-assessment tools and scaffolding of learning outcomes throughout the text.
The new authors continue the trusted pedagogy of the previous five editions and present approachable, balanced coverage to provide students with a solid biochemical foundation to prepare them for future scientific challenges. The pedagogy remains focused on biochemistry's key theme: the relationship between structure and function, while streamlining the student experience to better focus attention on the critical subject matter.
Fundamentals of Biochemistry 6e includes a significant update to the art program with modernized, more effective renderings that better enable understanding of the subject matter. New scaffolded learning outcomes in each section, and a focus on self-assessment tools, both streamline and elevate the effectiveness of the new edition as a critical learning resource for biochemistry students.
Contents
1 Introduction to the Chemistry of Life
The Origin of Life
Cellular Architecture
Thermodynamics
Problems
2 Water
Physical Properties of Water
Chemical Properties of Water
Problems
3 Amino Acids
Amino Acid Structure
Stereochemistry
Amino Acid Derivatives
Polypeptides and Proteins
Problems
4 Proteins: Three-Dimensional Structure
Secondary Structure
Tertiary Structure
Quaternary Structure and Multiprotein Complexes
Protein Folding and Unfolding
Biochemistry in Focus: Oxygen Transport
Problems
5 Carbohydrates
Monosaccharides
Polysaccharides
Glycoproteins
Problems
6 Nucleotides, Nucleic Acids, and Genetic Information
Nucleotides and Polynucleotides
Nucleic Acid Structure: DNA
Nucleic Acid Structure: RNA
Problems
7 Lipids and Biological Membranes
Lipid Classification
Lipid Bilayers
Membrane Proteins
Membrane Structure and Assembly
Problems
8 Membrane Transport
Thermodynamics of Transport
Passive-Mediated Transport
Active Transport
Problems
9 Enzymatic Catalysis
General Properties of Enzymes
Enzymes Work by Lowering Activation Energy
Mechanisms
Lysozyme
Serine Proteases
Problems
10 Enzyme Kinetics, Inhibition, and Control
Reaction Kinetics
Enzyme Inhibition
Control of Enzyme Activity
Biochemistry In Focus: Enzymes as Targets for Drug Design
Problems
11 Biochemical Signaling
Hormones
Receptor Tyrosine Kinases
Heterotrimeric G Proteins
The Phosphoinositide Pathway
Biochemistry in Focus: Chemical Signaling and Movement
Problems
12 Introduction to Metabolism
Overview of Metabolism
"High-Energy" Compounds
Oxidation-Reduction Reactions
Experimental Approaches to the Study of Metabolism
Problems
13 Glucose Catabolism
Overview of Glycolysis
The Reactions of Glycolysis
Metabolism of Hexoses Other than Glucose
Fermentation: The Anaerobic Fate of Pyruvate
Gluconeogenesis
Regulation of Glycolysis and Gluconeogenesis
The Pentose Phosphate Pathway
Problems
14 Glycogen Metabolism and Gluconeogenesis
Glycogen Breakdown
Glycogen Synthesis
Control of Glycogen Metabolism
Other Carbohydrate Biosynthetic Pathways
Problems
15 Citric Acid Cycle
Overview of the Citric Acid Cycle
Synthesis of Acetyl-SCoenzyme A
Enzymes of the Citric Acid Cycle
Regulation of the Citric Acid Cycle
Reactions Related to the Citric Acid Cycle
Problems
16 Electron Transport and Oxidative Phosphorylation
The Mitochondrion
Electron Transport
Oxidative Phosphorylation
Control of Oxidative Metabolism
Biochemistry in Focus: The Mitochondrion and Cell Death
Problems
17 Photosynthesis
Chloroplasts
The Light Reactions
The Dark Reactions
Problems
18 Lipid Metabolism
Lipid Digestion, Absorption, and Transport
Fatty Acid Oxidation
Fatty Acid Biosynthesis
Synthesis of Other Lipids
Cholesterol Metabolism
Problems
19 Amino Acid Metabolism
Protein Degradation
Amino Acid Deamination and the Urea Cycle
Breakdown of Amino Acids
Amino Acid Biosynthesis
Other Products of Amino Acid Metabolism
Biochemistry in Focus: Nitrogen Fixation
Problems
20 Mammalian Fuel Metabolism: Integration & Regulation
Organ Specialization
Hormonal Control of Fuel Metabolism
Metabolic Homeostasis: The Regulation of Energy Metabolism, Appetite, and Body Weight
Disturbances in Fuel Metabolism
Problems
21 Nucleotide Metabolism
Synthesis of Purine Ribonucleotides
Synthesis of Pyrimidine Ribonucleotides
Formation of Deoxyribonucleotides
Nucleotide Degradation
Problems
22 DNA Replication
Overview of DNA Replication
Prokaryotic DNA Replication
Eukaryotic DNA Replication
Problems
23 DNA Repair and Recombination
DNA Damage
DNA Repair
Recombination and Transposons
Problems
24 Transcription and RNA Processing
Prokaryotic RNA Transcription
Transcription in Eukaryotes
Posttranscriptional Processing
Problems
25 Protein Synthesis
The Genetic Code
Transfer RNA and Its Aminoacylation
Ribosomes
Translation
Posttranslational Processing
Problems
26 Regulation of Gene Expression
Genome Organization
Regulation of Prokaryotic Gene Expression
Regulation of Eukaryotic Gene Expression
The Cell Cycle, Cancer, Apoptosis, and Development
Appendix: Methods
