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Full Description
Understand the nature and applications of peptides with this clear and comprehensive guide
Peptides are signaling molecules comprised of amino acids which play an important role in modulating certain physiological processes. They have a wide range of applications, particularly with respect to biological studies and therapeutical potentials. The explosive growth of peptide science in recent years and the variety of achievements in peptide drug discovery and related areas have made it an important area of study for new researchers and industry professionals.
Peptide Science offers a clear, systematic overview of this burgeoning field and its major applications. Covering the chemistry, the pertinent technologies, and major existing therapies, it provides the tools required to integrate peptide research with virtually any area of research and development. Fully cognizant of the latest technological advances, it's a must-own for anyone looking to understand a vital field of chemistry.
Peptide Science readers will also find:
Through coverage of peptide hit generation technologies from nature, to various display libraries and to modern computational designs
Detailed discussion of therapies for conditions including cancer, diabetes, infectious diseases, and more
A section dedicated to key challenges and future directions in peptide therapeutics
Peptide Science is ideal for industry professionals and researchers in organic chemistry, peptide science/chemistry, protein chemistry, biochemistry, and pharmaceutical sciences.
Contents
CONTENTS
Preface
List of contributors
Section I. New Development in Peptide Chemistry
Chapter 1. Chemical Peptide Ligations
Chapter 2. Protein and Peptide Ligation Using Peptide Ligases
Chapter 3. Modern Methods for Late-Stage Peptide Modification
Section II. Peptide Drug Hit Identification
Chapter 4. From Natural Products to Peptide Drugs
Chapter 5. Generating Phage Libraries Bearing Unnatural Pharmacophores
Chapter 6. Computational Peptide Design for Diverse Structures and Functions
Section III. Peptide Drug Lead Generation and Optimization
Chapter 7. Peptide Discovery: Lead Generation
Chapter 8. A Survey and Guide to the Development of Fatty Acid-Derivatized Peptide Therapeutics
Section IV. Peptide Drug Case Studies
Chapter 9. Insulin In Its Second Century: History, Evolution and Aspirations
Chapter 10. Incretins and Development of Incretin-based Therapeutics
Chapter 11. Peptide-Based Therapeutics for Inflammatory and Autoimmune Diseases
Chapter 12. Radioligand as a Unique Rising Modality for Cancer Diagnosis and Treatment
Chapter 13. Peptide-Small Molecule Drug Conjugates for Cancer, Metabolic Diseases and Beyond
Chapter 14. Emerging Landscape of Therapeutic Oligonucleotide Delivery by Cell-Penetrating Peptide
Section V. Peptide CMC and Regulatory
Chapter 15. Peptide Chemistry, Manufacturing and Controls
