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Full Description
Patty's Toxicology was originally published as Patty's Industrial Hygiene and Toxicology in 1948 and has long been recognized as the premier reference for toxicological information on a large number of industrial chemicals. It includes comprehensive toxicological data for industrial compounds, including CAS numbers, physical and chemical properties, exposure limits, and biological tolerance values for occupational exposures.
The new edition provides updates for 90 chapters and features 20 new chapters. New Editors-in-Chief, and for the first time a group of Associate editors, bring a diverse new perspective and a more international focus.
Expanded with close to 1,000 more pages than the previous edition
New chapters added to the introductory volume of the book include Biotransformation of Xenobiotics, Toxicokinetics, Genetic Toxicology, Cancer Risk Assessment, Reproductive and Developmental Toxicology, and the setting of Occupational Exposure Limits
Several sections are reorganized and expanded including Agricultural Chemicals and Nanomaterials which covers Insecticides, Herbicides, Agricultural Triazole Fungicide, Rodenticides, Insect Repellents (DEET) and Others, and Combined Pesticide Exposure
Other new chapters include Diesel Exhaust, Occupational Biomonitoring, Toxicokinetics, Computational Toxicology, Genetic Toxicology, Immunotoxicology, Genetic Susceptibility in Occupational Health, Formaldehyde, Acrylates, and Silicones
An essential reference for industrial hygienists, toxicologists, occupational physicians, chemical hygiene officers, chemical plant managers, and reference libraries.
Contents
Volume 1 Part 1 Aspects of Occupational Toxicology 1
1 History and Trends in Industrial Toxicology 3
2 Regulations and Guidelines for Toxic Exposures in the Workplace 13
3 Occupational Safety and Health Act 41
4 European Union (EU) Industrial Chemicals Legislation and the Workplace 89
5 Chemical Toxicity Information Sources 107
6 Evolution of the Use of Toxicological Data for Evaluating Chemical Safety and Occupational Exposure Limits 141
7 Exposure Assessment 183
8 Principles and Information Sources for Occupational Biomonitoring 261
9 Animal Testing in the Twenty-First Century: A Review of Traditional Methodologies and Insights into Improving Outcomes by Optimizing Study Designs 279
Part 2 General Principles in Toxicology 317
10 Biotransformation 319
11 Toxicokinetics 363
12 Genetic Toxicology: Basics and Practical Insights into Its Appropriate Application 381
13 Immunotoxicology in Industrial Hygiene and Occupational Exposures 407
14 Neurotoxicology and Behavior 463
15 Endocrine Disruptors 493
16 Reproductive and Developmental Toxicology 531
17 Mechanisms of Action of Carcinogenic Chemicals Including Occupational Carcinogens 577
18 Computational Toxicology 599
19 Genetic Susceptibility in Occupational Health 617
20 Mixtures Risk Assessment: Available Methods and Future Directions 641
21 Noncancer Risk Assessment: Principles and Practice in Environmental and Occupational Settings 675
22 Occupational Exposure Limits for Chemical Agents 721
23 Health-Based Emergency Guidelines 765
24 Effects of Shift Work on Toxicology and Carcinogenesis 785
25 Ionizing Radiation 809
Volume 2
Part 3 Elements and Metals 1
26 Metallocenes 3
27 Silver and Gold 21
28 Beryllium 61
29 Magnesium 101 30 Calcium, Strontium, Barium, and Radium 111
31 Zinc and Zinc Compounds 127
32 Cadmium Compounds 161
33 Mercury 193
34 Aluminum Industrial Health and Safety 217
35 Gallium, Indium, and Thallium 243
36 Germanium, Tin, and Copper 333
37 Lead 373
38 Zirconium and Hafnium 423
40 Arsenic, Antimony, and Bismuth 495
41 Vanadium 545
42 Niobium 581
43 Tantalum 599
44 Chromium 613
45 Tungsten 637
46 Molybdenum 663
47 Manganese and Rhenium 697
48 Iron and Cobalt 733
49 Nickel and Its Compounds 755
50 Ruthenium, Rhodium, Palladium, and Osmium 783
51 Platinum 817
52 Uranium and Thorium 865
53 The Lanthanides, Rare Earth Elements 925
54 Phosphorus, Selenium, Tellurium, and Sulfur 955
55 Boron 1005
56 Alkaline Materials: Sodium, Potassium, Cesium, Rubidium, Francium, and Lithium 1057
57 Inorganic Compounds of Carbon, Nitrogen, and Oxygen 1077
Volume 3
Part 4 Oxygen-containing Hydrocarbons 1
58 Aliphatic Carboxylic Acids: Saturated 3
59 Aliphatic Carboxylic Acids: Unsaturated 77
60 Acetone 133
61 Ketones of Four or Five Carbons 151
62 Ketones of Six to Thirteen Carbons 207
63 Monohydric Alcohols: C1 to C6 319
64 Monohydric Alcohols — C7 to C22, Aromatic, and Other Alcohols 385
65 Esters of Mono- and Alkenyl Carboxylic Acids and Mono- and Polyalcohols 459
66 Esters of Tricarboxylic Acids 561
67 Esters of Carbonic and Orthocarbonic Acid, Organic Phosphorous, Monocarboxylic Halogenated Acids, Haloalcohols, and Organic Silicon 569
68 Epoxy Compounds — Olefin Oxides (Ethylene Oxide, Propylene Oxide, and Miscellaneous Oxides) 651
69 Aldehydes and Acetals 711
70 Glycidyl Ethers (Aliphatic Glycidyl Ethers, Aromatic Monoglycidyl Ethers, Aromatic Diglycidyl Ethers, Polyglycidyl Ethers) and Precursor Epoxy Compounds 827
71 Organic Peroxides 901
72 Glycols 987
73 Ethers of Ethylene Glycol and Derivatives 1045
74 Glycol Ethers: Ethers of Propylene, Butylene Glycols, and Other Glycol Derivatives 1197
75 Formaldehyde Exposure and Human Health Risks 1287
76 Esters of Monocarboxylic Acids 1315
Volume 4
Part 5 Hydrocarbons 1
77 Aliphatic Hydrocarbons 3
78 Alicyclic Hydrocarbons 129
79 Aromatic Hydrocarbons — Benzene and Other Alkylbenzenes 191
80 Styrene, Polyphenyls, and Related Compounds 249
81 Phenol and Phenolics 315
Part 6 Nitrogen Compounds 421
82 Aliphatic Nitro, Nitrate, and Nitrite Compounds 423
83 N-Nitroso Compounds 497
84 Aliphatic and Alicyclic Amines 509
85 Aromatic Nitro and Amino Compounds 631
86 Aromatic Amino and Nitro - Amino Compounds and Their Halogenated Derivatives 739
87 Selected Aliphatic and Aromatic Nitrogen Compounds 843
88 Alkylpyridines and Miscellaneous Organic Nitrogen Compounds 933
89 Cyanides and Nitriles 1119
Volume 5
Part 7 Halogenated Compounds 1
90 Halogenated One-Carbon Compounds 3
91 Saturated Halogenated Aliphatic Hydrocarbons Two to Three Carbons 43
92 Unsaturated Halogenated Hydrocarbons 85
93 Dibenzo-p-Dioxins: 2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Other Polychlorinated Dioxin-Like Chemicals 201
94 Polyhalogenated Biphenyls 219
95 Halogenated Benzenes 295
96 Esters of Aromatic Diacids (Phthalates) 353
Part 8 Fluorinated Chemicals 427
97 Organic Chlorofluoro Hydrocarbons 429
98 Organic Hydrofluoro-Olefins (HFOs) and Hydrochlorofluoro-Olefins (HCFOs) 505
99 Short-Chain Per/Polyfluoroalkyl Acids (C7 and Below) 549
100 Long Chain Per/Polyfluoroalkyl Acids (C8 and Above) 579
101 Selected Fluoropolymers (A Class of PFAS Polymers) 623
Part 9 Polymers 655
102 Synthetic Polymers 657
103 Synthetic Polymers — Olefin, Diene Elastomers, and Vinyl Halides 673
104 Polyvinyl Acetate, Alcohol and Derivatives, Polystyrene, and Acrylics 705
105 Synthetic Polymers — Cellulosics, Other Polysaccharides, Polyamides, and Polyimides 727
106 Synthetic Polymers: Polyesters, Polyethers, Polysulfones, and Other Polymers 775
107 Acrylate Esters (Acrylic Acid Esters) 815
108 Silicones 851
109 Miscellaneous Organic Polymers 865
Part 10 Pesticides 887
110 Organophosphorus Pesticides 889 111 Miscellaneous Chlorinated Hydrocarbon Pesticides 1051
112 Insecticides 1077
113 Herbicides 1103
114 Agricultural Triazole Fungicides 1123
115 Rodenticides 1155
116 Insect Repellents (DEET) and Others 1195
Volume 6
Part 11 Specialty Chemicals and Other Topics 1
117 Food Additives 3
118 Toxicology of Flavoring Ingredients in the Food Industry 25
119 Diacetyl 93
120 Toxicology of Mycotoxins 113
121 Engineered Nanomaterials 149
122 Occupational Health and Toxicological Aspects of Nanomaterials 165
123 Cotton and Other Textile Dusts 185
124 Silica and Silica Compounds 199
125 Serpentine and Amphibole Asbestos [A Subset of Elongated Mineral Particles (EMPs)] 249
126 Talc 309
127 Refractory Ceramic Fiber (Alumino Silicate Wool) 323
128 Rock/Stone Wool (Mineral Wool) 343
129 Coal Dust 359
130 Coal Tar, Crude Oil, and Derived Products 387
131 Polycyclic Aromatic Hydrocarbons, Methylated Polycyclic Aromatic Hydrocarbons, and Polycyclic Azaaromatic Compounds 437
132 Carbon Black 511
133 Wood Dust 535
134 Generation and Toxicity of Smoke and Combustion-Related Fire Products 587
135 Diesel Engine Emissions 599
136 Fiberglass (Glass Wool) 607
137 Metalworking Fluids (MWFs) 615
138 Toxicology of Cosmetics 627
139 Flame Retardant Chemicals 657
Part 12 Miscellaneous 693
140 Organic Sulfur Compounds 695
141 Occupational Toxicology in the Pharmaceutical Industry 749
142 Chemicals Used in the Electronics Industry 789
143 Electronic Waste: Human Health and Environmental Risk 839
144 Chemical Alternatives Assessment 857
145 Airborne Particles 891
Cumulative Subject Index, Volumes 1 - 6 915
Cumulative Chemical Index, Volumes 1 - 6 1081
Cumulative CAS Index, Volumes 1 - 6
