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Full Description
Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses.
• Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies
• Uses a didactic approach with basic biological or theoretical background for the methodology presented
• Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology
• Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts
• "A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses" - BTS Newsletter review of the 4th edition
Contents
Preface xxix
List of Contributors xxxi
Section 1 Introduction 1
1 Molecular and Biochemical Toxicology: Definition and Scope 3
Ernest Hodgson and Robert C. Smart
Section 2 Techniques in Biochemical and Molecular Toxicology 11
2 Molecular Techniques for the Study of Gene Function 13
Yoshiaki Tsuji and Robert C. Smart
3 Transcriptomics 55
B. Alex Merrick
4 Proteomics 91
Michael S. Bereman
5 Metabolomics 115
Susan C. J. Sumner, Wimal Pathmasiri, James E. Carlson, Susan L. McRitchie, and Timothy R. Fennell
6 Cellular Techniques 135
Sharon A. Meyer and Barbara A. Wetmore
7 Basic Concepts of Molecular Epidemiological Research Methods 159
Cathrine Hoyo, David A. Skaar, and Randy L. Jirtle
Section 3 Mechanisms in Molecular and Biochemical Toxicology 187
8 Phase I and Phase II Metabolism and Metabolic Interactions: A Summary 189
Ernest Hodgson
9 Structure, Mechanism, and Regulation of Cytochromes P 450 209
John M. Seubert, Matthew L. Edin, and Darryl C. Zeldin
10 Polymorphisms in Phase I and Phase II Genes and Outcomes 239
Yoshiaki Tsuji, Edward L. Croom, and Ernest Hodgson
11 Cellular Transport and Elimination 273
David S. Miller and Ronald E. Cannon
12 Nuclear Receptors 293
Seth W. Kullman, William S. Baldwin, and Gerald A. LeBlanc
13 Mechanisms of Cell Death 327
Mac Law and Susan Elmore
14 Mitochondrial Dysfunction 371
Jun Ninomiya-Tsuji
15 Reactive Metabolites, Reactive Oxygen Species (ROS), and Toxicity 391
Elizabeth L. MacKenzie and Yoshiaki Tsuji
16 DNA Damage and Mutagenesis 421
Zhigang Wang
17 DNA Repair 485
Isabel Mellon
18 Carcinogenesis 535
Robert C. Smart and Jonathan R. Hall
Section 4 Molecular and Biochemical Aspects of Organ Toxicology 589
19 Molecular Mechanisms of Respiratory Toxicity 591
James C. Bonner
20 Molecular Mechanisms of Hepatotoxicity 629
Supriya R. Kulkarni, Andrew D. Wallace, Sharon A. Meyer, and Angela L. Slitt
21 Molecular Mechanisms of Renal Toxicology 665
Lawrence H. Lash
22 Molecular Mechanisms of Neurotoxicity 709
Kimberly P. Keil, Marianna Stamou, and Pamela J. Lein
23 Molecular Mechanisms of Immunotoxicity 773
Tai L. Guo, Joella Xu, Yingjia Chen, Daniel E. Lefever, Guannan Huang, and David A. Lawrence
24 Molecular Mechanisms of Reproductive Toxicity 823
Ayelet Ziv-Gal, Catheryne Chiang, and Jodi Anne Flaws
25 Molecular Mechanisms of Developmental Toxicity 851
Antonio Planchart
Section 5 Emerging Areas in Molecular and Biochemical Toxicology 877
26 Computational and Molecular Approaches to Risk Assessment 879
Richard S. Judson, John Wambaugh, Kristin Isaacs, and Russell S. Thomas
27 Nanotoxicology 909
James C. Bonner
28 Developmental Origins of Health and Disease 933
Michael Cowley
29 Exposome 945
Stephen M. Rappaport
Index 969
