Full Description
With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action - the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics.
• Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students
• Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs
• Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties
• Focuses on structure-function relationships of drug targets - informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development
• Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, and all figures and tables from the book
Contents
LIST OF CONTRIBUTORS xlvi
Preface xlix
SECTION 1 INTRODUCTION TO PHARMACOLOGY 1
1 Essential Lexicon of Pharmacology 3
Francesco Clementi and Guido Fumagalli
2 A Short History of Pharmacology 8
Vittorio A. Sironi
SECTION 2 GETTING THE DRUG TO ITS SITE OF ACTION 19
3 Cellular Basis of Pharmacokinetics 21
Riccardo Fesce and Guido Fumagalli
4 Drug Absorption and Administration Routes 31
Riccardo Fesce and Guido Fumagalli
5 Drug Distribution and Elimination 45
Riccardo Fesce and Guido Fumagalli
6 Drug Metabolism 61
Enzo Chiesara Laura Marabini and Sonia Radice Metabolic Modification of Drug Activity
7 Control of Drug Plasma Concentration 73
Riccardo Fesce and Guido Fumagalli
SECTION 3 RECEPTORS AND SIGNAL TRANSDUCTION 91
8 Drug-Receptor Interactions: Quantitative and Qualitative Aspects 93
Gian Enrico Rovati and Valérie Capra
9 Receptors and Modulation of Their Response 109
Francesco Clementi and Guido Fumagalli
10 A daptation to Drug Response and Drug Dependence 121
Cristiano Chiamulera
11 Pharmacological Modulation of Posttranslational Modifications 130
Monica Di Luca Flavia Valtorta and Fabrizio Gardoni
12 Calcium Homeostasis Within the Cells 139
Jacopo Meldolesi and Guido Fumagalli
13 Pharmacology of Map Kinases 147
Lucia Vicentini and Maria Grazia Cattaneo
14 Small G Proteins 154
Erzsébet Ligeti and Thomas Wieland
15 Integration in Intracellular Transduction of Receptor Signals 166
Jacopo Meldolesi
SECTION 4 RECEPTOR CLASSES 173
16 Ligand-Gated Ion Channels 175
Cecilia Gotti and Francesco Clementi
17 G-Protein-Coupled Receptors 189
Lucia Vallar Maria Pia Abbracchio and Lucia Vicentini
18 Growth Factor Receptors 202
Silvia Giordano Carla Boccaccio and Paolo M. Comoglio
19 Cytokine Receptors 217
Massimo Locati
20 A dhesion Molecule Receptors 225
Giorgio Berton and Carlo Laudanna
21 Soluble Cytokine Receptors and Monoclonal Antibodies in Pathophysiology and Therapy 235
Alberto Mantovani and Annunciata Vecchi
SECTION 5 MODULATION OF GENE ESPRESSION 241
22 Pharmacology of Transcription 243
Roberta Benfante and Diego Fornasari
23 Pharmacogenetics and Personalized Therapy 256
Diego Fornasari
24 Intracellular Receptors 268
Adriana Maggi and Elisabetta Vegeto
25 Rna Molecule as a Drug: From Rna Interference to Aptamers 284
Valerio Fulci and Giuseppe Macino
SECTION 6 REGENERATIVE MEDICINE 293
26 Regenerative Medicine and Gene Therapy 295
Luciano Conti and Elena Cattaneo
SECTION 7 PHARMACOLOGICAL CONTROL OF MEMBRANE TRANSPORT 309
27 Ion Channels 311
Maurizio Taglialatela and Enzo Wanke
28 Membrane Transporters 345
Lucio Annunziato Giuseppe Pignataro and Gianfranco Di Renzo
29 Neurotransmitter Transporters 359
Gaetano Di Chiara
SECTION 8 CONTROL OF PROTEOLYSIS 377
30 Intracellular Proteolysis 379
Fabio Di Lisa and Edon Melloni
31 Extracellular Proteolysis 395
Francesco Blasi
SECTION 9 CONTROL OF CELL CYCLE AND CELLULAR PROLIFERATION 403
32 Cell Cycle and Cell Death 405
Marco Corazzari and Mauro Piacentini
33 Mechanisms of Action of Antitumor Drugs 415
Giovanni Luca Beretta Laura Gatti and Paola Perego
SECTION 10 CONTROL OF CELLULAR METABOLISM 431
34 Mitochondria Oxidative Stress and Cell Damage: Pharmacological Perspectives 433
Clara De Palma Orazio Cantoni and Fabio Di Lisa
35 Pharmacological Control of Lipid Synthesis 439
Lorenzo Arnaboldi Alberto Corsini and Nicola Ferri
36 Glucose Transport and Pharmacological Control of Glucose Metabolism 452
Paolo Moghetti and Giacomo Zoppini
SECTION 11 INTERCELLULAR COMMUNICATION 463
37 Pharmacological Regulation of Synaptic Function 465
Michela Matteoli Elisabetta Menna Costanza Capuano and Claudia Verderio
38 Catecholaminergic Transmission 477
Pier Franco Spano Maurizio Memo M. Cristina Missale Marina Pizzi and Sandra Sigala
39 Cholinergic Transmission 496
Giancarlo Pepeu
40 The Serotonergic Transmission 509
Maurizio Popoli Laura Musazzi and Giorgio Racagni
41 Histaminergic Transmission 520
Emanuela Masini and Laura Lucarini
42 Gabaergic Transmission 529
Mariangela Serra Enrico Sanna and Giovanni Biggio
43 Glutamate-Mediated Neurotransmission 541
Flavio Moroni
44 Purinergic Transmission 553
Stefania Ceruti Flaminio Cattabeni and Maria Pia Abbracchio
45 Neuropeptides 565
Lucia Negri and Roberta Lattanzi
46 The Opioid System 572
Patrizia Romualdi and Sanzio Candeletti
47 The Endocannabinoid System 585
Daniela Parolaro and Tiziana Rubino
48 Pharmacology of Nitric Oxide 596
Emilio Clementi
49 A rachidonic Acid Metabolism 608
Carlo Patrono and Paola Patrignani
SECTION 12 PHARMACOLOGY OF DEFENCE PROCESSES 623
50 Pharmacological Modulation of the Immune System 625
Carlo Riccardi and Graziella Migliorati
51 Mechanism of Action of Anti-Infective Drugs 641
Francesco Scaglione
SECTION 13 TOXICOLOGY AND DRUG INTERACTIONS 663
52 Introduction to Toxicology 665
Helmut Greim
53 Drug Interactions 678
Achille P. Caputi Giuseppina Fava and Angela De Sarro
SECTION 14 DRUG DEVELOPMENT 687
54 Preclinical Research and Development of New Drugs 689
Ennio Ongini
55 Role of Drug Metabolism and Pharmacokinetics in Drug Development 700
Simone Braggio and Mario Pellegatti
56 Clinical Development of a New Drug and Methodology of Drug Trials 708
Carlo Patrono
Index 714
