Full Description
The fully updated 12th edition of an essential reference for anyone responsible for prescribing drugs for patients with mental health disorders.A well-respected and widely-used source of information on which drugs to prescribe, which side effects to look out for, how best to augment or switch drugs, and moreProvides concise reviews of psychiatric disorders and relevant psychopharmacology, along with general guidance based on the data reviewed and current clinical practiceIncludes specific guidance for schizophrenia, bipolar disorder, depression, anxiety, substance abuse, and special populations such as children, the elderly and pregnant womenEach section features a full reference list so the evidence base can be checked quickly and easilyThis title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.
Contents
Preface xi Acknowledgements xiiNotes on using The Maudsley Prescribing Guidelines xiiiList of abbreviations xvChapter 1 Plasma level monitoring of psychotropic drugs 1Interpreting sample results 2Acting on clozapine plasma concentration results 11Interpreting post-mortem blood concentrations 13Chapter 2 Schizophrenia 15Antipsychotic drugs 15General introduction 15General principles of prescribing 20Minimum effective doses 22Quick reference for licensed maximum doses 24Equivalent doses 26High-dose antipsychotics: prescribing and monitoring 28Antipsychotic prophylaxis 31Combined antipsychotics 37Negative symptoms 41Monitoring 45Relative adverse effects a rough guide 48Treatment algorithms for schizophrenia 49First ]generation antipsychotics place in therapy 52Omega-3 fatty acid (fish oils) in schizophrenia 54New and developing drugs to treat schizophrenia 56NICE guidelines for the treatment of schizophrenia 59Antipsychotic response to increase the dose, to switch, to add or just wait what is the right move? 61Antipsychotic long ]acting injections 66Depot antipsychotics pharmacokinetics 70Management of patients on long ]term depots 72Aripiprazole LAI 74Olanzapine LAI 75Paliperidone palmitate LAI 77Risperidone LAI 80ANTIPSYCHOT ICS ADVERSE EFFECTS 84Extrapyramidal side-effects 84Akathisia 88Weight gain 90Treatment of drug-induced weight gain 92Tardive dyskinesia 97Neuroleptic malignant syndrome 102Catatonia 105QT prolongation 110Dyslipidaemia 117Diabetes and impaired glucose tolerance 121Hypertension 128Hyponatraemia 130Hyperprolactinaemia 133Sexual dysfunction 137Pneumonia 143Switching antipsychotics 144REFRACTORY SCHIZOPHRENIA AND CLOZAPINE 147Clozapine dosing regimen 147Optimising clozapine treatment 149Alternatives to clozapine 153Restarting clozapine after a break in treatment 159Initiation of clozapine for community-based patients 160CLOZAPINE ADVERSE EFFECTS 165Common adverse effects 165Clozapine: uncommon or unusual adverse effects 168Clozapine: serious haematological and cardiovascular adverse effects 170Clozapine-induced hypersalivation 174Clozapine-induced gastrointestinal hypomotility (CIGH) 177Clozapine, neutropenia and lithium 181Clozapine and chemotherapy 186Chapter 3 Bipolar affective disorder 189Lithium 189Valproate 197Carbamazepine 203Antipsychotics in bipolar disorder 208Treatment of acute mania or hypomania 211Bipolar depression 216Rapid-cycling bipolar affective disorder 223Prophylaxis in bipolar affective disorder 225Physical monitoring for people with bipolar affective disorder 228Chapter 4 Depression and anxiety 231Introduction 231Basic principles of prescribing in depression 231Official guidance on the treatment of depression 232Antidepressants: general overview 233St John s wort 246Recognised minimum effective doses of antidepressants 250Drug treatment of depression 252Treatment of refractory depression 255Psychotic depression 266Electroconvulsive therapy and psychotropic drugs 269Psychostimulants in depression 272Post-stroke depression 276Treatment of depression in the elderly 279Antidepressant discontinuation symptoms 283Antidepressant prophylaxis 287Antidepressants: alternative routes of administration 290Antidepressants: swapping and stopping 296Drug interactions with antidepressants 303Cardiac effects of antidepressants 307Antidepressant-induced arrhythmia 312Antidepressant-induced hyponatraemia 316Antidepressants and hyperprolactinaemia 319Antidepressants and diabetes mellitus 321Antidepressants and sexual dysfunction 324SSR Is and bleeding 328Antidepressants: relative adverse effects a rough guide 332Anxiety spectrum disorders 334Benzodiazepines in the treatment of psychiatric disorders 343Benzodiazepines: dependence and detoxification 346Benzodiazepines and disinhibition 350Chapter 5 Children and adolescents 353Principles of prescribing practice in childhood and adolescence 353Depression in children and adolescents 355Bipolar illness in children and adolescents 362Psychosis in children and adolescents 367Anxiety disorders in children and adolescents 369Obsessive compulsive disorder in children and adolescents 374Post-traumatic stress disorder in children and adolescents 379Attention deficit hyperactivity disorder 384Autism spectrum disorders 390Tics and Tourette s syndrome 397Melatonin in the treatment of insomnia in children and adolescents 402Rapid tranquillisation in children and adolescents 405Doses of commonly used psychotropic drugs in children and adolescents 408Chapter 6 Substance misuse 409Introduction 409Alcohol dependence 411Opioid misuse and dependence 429Nicotine and smoking cessation 456Pharmacological treatment of dependence on stimulants 463Benzodiazepine misuse 466GBL and GHB dependence 467Drugs of misuse: a summary 469Interactions between street drugs and prescribed psychotropic drugs 472Chapter 7 Use of psychotropic drugs in special patient groups 477The elderly 477Dementia 487Safer prescribing of physical health medicines in dementia 507Management of non-cognitive symptoms of dementia 517Parkinson s disease 529Multiple sclerosis 533Huntington s disease 538Pregnancy 541Breastfeeding 559Renal impairment 576Hepatic impairment 590HIV infection 598Eating disorders 607Acutely disturbed or violent behaviour 611Borderline personality disorder 618Learning disabilities 621Delirium 625Epilepsy 632Surgery 637Velo-cardio-facial syndrome 643Cytochrome (CY P) function 646Psychiatric side-effects of non-psychotropic drugs 650Atrial fibrillation 656Chapter 8 Miscellaneous conditions and substances 659Psychotropic drugs in overdose 659Biochemical and haematological effects of psychotropics 665Prescribing drugs outside their licensed indications ( off-label prescribing) 673Observations on the placebo effect in mental illness 676Drug interactions with alcohol 679Nicotine 684Smoking and psychotropic drugs 688Caffeine 690Complementary therapies 695Enhancing medication adherence 700Driving and psychotropic medicines 706Covert administration of medicines within food and drink 714Index 717
