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Full Description
Discover the experimental and theoretical developments in optical single-molecule spectroscopy that are changing the ways we think about molecules and atoms The Advances in Chemical Physics series provides the chemical physics field with a forum for critical, authoritative evaluations of advances in every area of the discipline. This latest volume explores the advent of optical single-molecule spectroscopy, and how atomic force microscopy has empowered novel experiments on individual biomolecules, opening up new frontiers in molecular and cell biology and leading to new theoretical approaches and insights. Organized into two parts—one experimental, the other theoretical—this volume explores advances across the field of single-molecule biophysics, presenting new perspectives on the theoretical properties of atoms and molecules. Single-molecule experiments have provided fresh perspectives on questions such as how proteins fold to specific conformations from highly heterogeneous structures, how signal transductions take place on the molecular level, and how proteins behave in membranes and living cells.This volume is designed to further contribute to the rapid development of single-molecule biophysics research.
Filled with cutting-edge research reported in a cohesive manner not found elsewhere in the literature, each volume of the Advances in Chemical Physics series serves as the perfect supplement to any advanced graduate class devoted to the study of chemical physics.
Contents
Preface xiii Part One Developments on Single-Molecule Experiments
Staring at a Protein: Ensemble and Single-Molecule Investigations on Protein-Folding Dynamics 3
By Satoshi Takahashi and Kiyoto Kamagata
Single-Molecule FRET of Protein-Folding Dynamics 23
By Daniel Nettels and Benjamin Schuler
Quantitative Analysis of Single-Molecule FRET Signals and its Application to Telomere DNA 49
By Kenji Okamoto and Masahide Terazima
Force to Unbind Ligand-Receptor Complexes and the Internal Rigidity of Globular Proteins Probed by Single-Molecule Force Spectroscopy 71
By Atsushi Ikai, Rehana Afrin, and Hiroshi Sekiguchi
Recent Advances in Single-Molecule Biophysics with the Use of Atomic Force Microscopy 89
By Masaru Kawakami and Yukinori Taniguchi
Dynamical Single-Molecule Observations of Membrane Protein Using High-Energy Probes 133
By Yuji C. Sasaki
Single-Molecular Gating Dynamics for the KcsA Potassium Channel 147
By Shigetoshi Oiki, Hirofumi Shimizu, Masayuki Iwamoto, and Takashi Konno
Static and Dynamic Disorder in IN VITRO Reconstituted Receptor-Adaptor Interaction 195
By Hiroaki Takagi, Miki Morimatsu, and Yasushi Sako
Part Two Developments on Single-Molecule Theories and Analyses
Change-Point Localization and Wavelet Spectral Analysis of Single-Molecule Time Series 219
By Haw Yang
Theory of Single-Molecule FRET Efficiency Histograms 245
By Irina V. Gopich and Attila Szabo
Multidimensional Energy Landscapes in Single-Molecule Biophysics 299
By Akinori Baba and Tamiki Komatsuzaki
Generalized Michaelis-Menten Equation for Conformation Modulated Monomeric Enzymes 329
By Jianlan Wu and Jianshu Cao
Making it Possible: Constructing a Reliable Mechanism from a Finite Trajectory 367
By Ophir Flomenbom
Free Energy Landscapes of Proteins: Insights from Mechanical Probes 395
By Zu Thur Yew, Peter D. Olmsted, and Emanuele Paci
Mechanochemical Coupling Revealed by the Fluctuation Analysis of Different Biomolecular Motors 419
By Hiroaki Takagi and Masatoshi Nishikawa
Author Index 437
Subject Index 467
