Continuous Biopharmaceutical Processes : Chromatography, Bioconjugation, and Protein Stability (Cambridge Series in Chemical Engineering)

Pfister, David/ Nicoud, Lucrèce/ Morbidelli, Massimo

Cambridge University Press（2018/10発売）

• 製本 Hardcover:ハードカバー版／ページ数 346 p.
• 言語 ENG
• 商品コード 9781108420228
• DDC分類 615.7

Full Description

This innovative reference provides a coherent and critical view on the potential benefits of a transition from batch to continuous processes in the biopharmaceutical industry, with the main focus on chromatography. It also covers the key topics of protein stability and protein conjugation, addressing the chemical reaction and purification aspects together with their integration. This book offers a fine balance between theoretical modelling and illustrative case studies, between fundamental concepts and applied examples from the academic and industrial literature. Scientists interested in the design of biopharmaceutical processes will find useful practical methodologies, in particular for single-column and multi-column chromatographic processes.

Contents

Preface; 1. Introduction to biopharmaceutical processes; 2. Fundamentals of protein chromatography; 3. Counter-current separation processes; 4. Counter-current chromatography for the capture step; 5. Counter-current chromatography for the polishing steps; 6. Protein conjugation; 7. Protein aggregation in biopharmaceutical processes; 8. Conclusion; References; Notation; Index.