Full Description
This volume considers the current techniques used by experts to study and measure cerebellar function. The chapters in this book cover topics such as stem cell-based techniques; conditional genetics approaches in model systems; neuronal recordings conducted in vitro and in vivo; and an ever-growing list of behavioral paradigms. This book also provides readers with a guide for how to use tools such as iPSCs and how to address questions using a range of approaches in animal model systems including mouse, rat, zebrafish, and non-human primate. In the Neuromethods series style, the chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Cutting-edge and authoritative, Measuring Cerebellar Function is a valuable resource for cerebellar enthusiasts and other scientists interested in learning more about the cerebellum and the technological advances that are currently being employed to unlock brain function and understand animal behavior.
Contents
Cerebellar Modeling using Human Induced Pluripotent Stem Cells.- From Cerebellar Genes to Behaviors in Zebrafish.- Silencing the Output of Cerebellar Neurons using Cell Type-Specific Genetic Deletion of Vesicular GABA and Glutamate Transporters.- Mapping Structure-Function Relationships within Cerebellar Circuits.- Designing Behavioral Tasks for Cerebellar Functional Analysis in the Mouse.- Learning Paradigms and Genetic Tools for the Study of Cerebellum-Dependent Learning and Memory.- Neural Circuit Activity Dependent Chromatin Mechanisms in Cerebellar Motor Learning.- In Vitro Voltage Imaging of Subthreshold Activity in Inferior Olive Neurons with ANNINE-6plus.- Mapping Synaptic Connectivity in the Cerebellar Cortex using RuBi-Glutamate Uncaging.- Multisite Extracellular Electrode Neuronal Recordings in the Rodent Cerebellar Cortex and Nuclei.- Investigating Cerebrocerebellar Neuronal Interactions in Freely Moving Mice using Multi-Electrode, Multi-Site Recordings.- In Vivo Optical Detection of Membrane Potentials in the Cerebellum: Voltage Imaging of Zebrafish.- Imaging Neuronal Activity in Cerebellar Cortex of Behaving Mice.- Measuring Cerebellar Processing and Sensorimotor Functions in Non-Human Primates.- Optogenetics in Complex Model Systems (Non-Human Primate).- Clinical Assessment of the Cerebellum.
