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Full Description
This book provides a comprehensive review of the emerging role of extrachromosomal DNA (ecDNA) in cancer, highlighting its significance in tumor progression, oncogene amplification, drug resistance, and clinical applications. Extrachromosomal DNA in Cancer: Mechanisms, Biomarkers, and Therapeutic Implications explores the structural and functional characteristics of ecDNA, emphasizing its role in shaping the genetic and epigenetic landscapes of cancer cells. The book discusses the impact of ecDNA on tumor heterogeneity, metastasis, and immune evasion, providing insights into how ecDNA contributes to cancer evolution and therapeutic resistance. The text also examines cutting-edge imaging techniques, computational approaches, and non-invasive diagnostic applications of ecDNA, highlighting its potential as a biomarker in precision oncology. Additionally, it presents the novel therapeutic strategies targeting ecDNA, addressing challenges and opportunities in integrating these insights into cancer treatment.
Features
Explores the structural formation and oncogenic role of ecDNA in tumor development and progression
Discusses the influence of ecDNA on gene expression, epigenetics, and immune modulation in cancer
Examines the role of ecDNA in drug resistance, metastasis, and disease recurrence
Highlights advanced imaging, computational tools, and non-invasive diagnostic applications of ecDNA
Reviews emerging therapeutic strategies targeting ecDNA for improved cancer treatment and personalized medicine
This book is intended for researchers and students of cancer biology, molecular biology, and biotechnology.
Contents
Chapter 1 Overview of ecDNA: Discovery and Emerging Significance in Cancer. Chapter 2 Formation and Structure of ecDNA in Cancer Cells. Chapter 3 ecDNA in Oncogene Amplification and Tumor Progression. Chapter 4 Gene Expression and Epigenetic Landscapes of ecDNA in Cancer. Chapter 5 EcDNA: Role in Cancer Drug Resistance. Chapter 6 Imaging, Visualization and characterization of ecDNA in Cancer Cells. Chapter 7 Extrachromosomal DNA in Non-Invasive Cancer Diagnostics. Chapter 8 Extra-chromosomal DNA (ecDNA) as Diagnostic Biomarkers for Cancers. Chapter 9 ecDNA Knowledge for Personalized Medicines. Chapter 10 ecDNA formation: Tumor Immune Escape. Chapter 11 The Role of ecDNA in Tumor Heterogeneity and Evolution. Chapter 12 Role of ecDNA in Cancer Metastasis and Disease Recurrence. Chapter 13 Computational Approaches to Study EcDNA in Cancer Genomics. Chapter 14 ecDNA and Immune Modulation: Progress and Challenges of Cancer Immunotherapy. Chapter 15 Extrachromosomal DNA (ecDNA) and Clinical Implications in Cancer. Chapter 16 Targeting ecDNA: Novel Therapeutic Approach.
