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Full Description
This book provides a comprehensive review of the advancements in cell-free therapeutic applications, focusing on the biological and biomedical potential of mesenchymal stem cell (MSC)-derived secretome and extracellular vesicles (EVs) in disease treatment and tissue repair. It examines the mechanistic functions of MSC-derived biomolecules and the regulatory landscape shaping their development. The discussion then progresses to innovative strategies for enhancing the MSC secretome through priming techniques, optimizing its biological activity for therapeutic applications. The book examines the application of exosome-based and EV-driven therapies across a broad range of biomedical fields, including neuroscience, cardiology, ophthalmology, gastroenterology, and oncology. Further, it highlights the role of MSC-derived secretome in treating neurocognitive disorders, autoimmune diseases, diabetes complications, and inflammatory conditions, with a special focus on innovations in drug delivery, tissue repair. Additionally, it examines the emerging use of EVs as theranostic tools in cancer therapy and their application in novel treatment strategies for COVID-19. The book also addresses key challenges in transitioning these cell-free therapies from bench to bedside, covering critical aspects such as formulation, large-scale production, regulatory approvals, and clinical implementation.
Key Features:
1) Explores the biomedical applications of MSC-derived secretome and EVs across different diseases.
2) Discusses the biological and therapeutic potential of exosome-based treatments for neurodegenerative, cardiovascular, ophthalmological, and metabolic diseases.
3) Examines innovations in extracellular vesicle-based cell-free therapies for targeted tissue repair and disease intervention.
4) Reviews the challenges of translating EV-based therapeutics into clinical practice, including regulatory and manufacturing considerations.
5) Highlights cutting-edge applications of EVs in oncology, infectious diseases, and theranostics.
This book serves as an important resource for researchers and students of biomedical engineering, biotechnology, and stem cell biology.
Contents
Chapter 1: Living Biodrugs MSCs-Derived Exosomes and Secretome as Advanced Therapeutic Products (ATMPs) for The Treatment of COVID-19. Chapter 2: Paracrining the heart with stem cell secretome: Mechanism of action, ethical considerations, and regulatory framework for development as Advanced Treatment Medicinal Products. Chapter 3: Cell-free therapy: next step in regenerative medicine. Chapter 4: Harnessing the Secretome to Repair Electrical Conductivity in the Heart. Chapter 5: The MSC-derived secretome-based therapy for neuroinflammation in traumatic brain injury. Chapter 6: Therapeutic Potential of Secretome in Ophthalmic Disorders. Chapter 7: The potential of extracellular vesicles in regenerative medicine. Chapter 8: Vesicle-Based Cell-Free Therapy in Liver Diseases: A Promising Therapeutic Frontier. Chapter 9: Potential therapies using engineered mesenchymal stem cell-derived exosomes in gastrointestinal diseases. Chapter 10: Stem Cell Exosomes: Nature's Nanoparticles for Respiratory Disorders. Chapter 11: The Role of Exosomes in Primary Sjögren's Syndrome—Pathogenesis, Diagnostics, and Therapeutics. Chapter 12: MSC-derived exosomes for the therapy of diabetes mellitus and associated complications. Chapter 13: The use of mesenchymal stem cell-sourced exosomes in the treatment of neurocognitive disease: from bench to bedside. Chapter 14: The utilization of exosome-derived secretome in cardiac repair in heart failure. Chapter 15: Living Biodrugs and Their Derived Advanced Therapy Medicinal Products to Treat Autoimmune Pathologies. Chapter 16: Mesenchymal Stem Cells in Knee Osteoarthritis: Mechanisms, Evidence, and Future Directions. Chapter 17: Stem Cells Extracellular Vesicles and Autoimmune Disease. Chapter 18: Theragnostic uses of Exosomes. Chapter 19: Exosome Engineering for Enhanced Therapeutic Activity. Chapter 20: Osteoimmunology and Intercellular Communication: The Role of The Secretome and Extracellular Vesicles in Bone Regeneration. Chapter 21: Advancing Regenerative Medicine: The Role of Secretome and Extracellular Vesicles in Bone and Cartilage Disorders. Chapter 22: Mesenchymal Stem Cell-Derived Secretome and Extracellular Vesicles: Therapeutic Innovations for Nervous System Disorders. Chapter 23: Exosomes and Secretome in Uro-Genital Medicine: Beyond Cellular Therapies. Chapter 24: Advances in Cell-Derived Exosomes and Secretomes From Bench to Bedside in Oncology. Chapter 25: Engineering Exosome-Based Therapy: Therapeutic Potential and Limitations. Chapter 26: The use of secretome and extracellular vesicles in regenerative medicine. Chapter 27: Diabetes Mellitus: Treatment with MSCs and their Secretome.
