Full Description
This book comprehensively reviews cell-free therapy approaches, focusing on the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles (EVs) and secretomes across various reparative and regenerative medicine fields. The initial chapters primarily provide foundational insights into the application of EVs in dentistry, cardiovascular pathologies, and kidney injury. Each chapter discusses the role of mesenchymal stem cell exosomes in targeted therapies for conditions like neurodegenerative disorders, ophthalmological diseases, and diabetes complications, examining the applications of EV-based techniques in personalized medical strategies. The subsequent chapters discuss the advanced diagnostic and therapeutic applications, including using EVs as biomarkers in liquid biopsies and novel tissue engineering and cell-free scaffolding techniques for organ rejuvenation and tissue regeneration. Additionally, this book examines the challenges and progress in transitioning these therapies from laboratory research to clinical applications, covering critical aspects of formulation, Good Manufacturing Practice (GMP) production, regulatory approval, and market access. With insights into emerging technologies like 3D cell scaffolding and theragnostic applications in cancer and neurodegenerative diseases, this book emphasizes the future of a cell-free approach in regenerative medicine. This book is a useful resource for researchers and students in regenerative medicine.
Key Features:
Provides insights into EV-based therapies and their role in regenerative medicine across multiple medical fields
Discusses the potential of mesenchymal stem cell-derived exosomes in treating neurodegenerative, ophthalmological, and cardiovascular conditions
Explores cell-free scaffolding for targeted tissue and organ regeneration
Reviews the current regulatory, production, and clinical challenges in bringing cell-free therapies to market
Explores cutting-edge theragnostic applications of EVs in oncology and neurological disorders
Contents
About the Editor. List of Contributors. Chapter 1 Extracellular Vesicles as in Dentistry from Laboratory to Clinic. Chapter 2 Extracellular Vesicles-Based Cell-Free Therapies in Cardiovascular Diseases. Chapter 3 Regenerative Therapy with Extracellular Vesicles in Acute and Chronic Kidney Injury. Chapter 4 Isolation and Characterization of IPSC EVs Preconditioned with Severe Critically Ill COVID-19 Patient's Serum. Chapter 5 Therapeutic Efficacy of Mesenchymal Stem Cells and Their Derived Exosomes in Different Neurodegenerative Disorders: Current Status and Future Perspectives. Chapter 6 Applications and Implications of Mesenchymal Stem Cell-Derived Exosomes in Ophthalmology. Chapter 7 Future Management of Type 2 Diabetes and Its Complications by Mesenchymal Stem Cell-Derived Exosomes (MSC-Exos). Chapter 8 Liquid Biopsy Biomarkers for Personalized Management in Heart Failure. Chapter 9 Prospective Implications of Autologous Platelet-Rich Plasma in Tissue Engineering and Organ Rejuvenation. Chapter 10 Cell-Free and Cell-Based Therapy in Regenerative Medicine. Chapter 11 Mesenchymal Cell-Free and Cell-Based Therapy in Regenerative Medicine: A Crucial Exploration of Formulation, GMP Production, Regulatory Approval, and Market Access. Chapter 12 Unveiling Mesenchymal Stem Cells Secretome Potentials in Regenerative Medicine and Disease Therapeutics. Chapter 13 Engineering Therapeutic Mesenchymal Stem Cells Secretome for Bone Regeneration. Chapter 14 Cell-Free Scaffolding: A Tissue-Engineering Approach with the Potential to Revolutionize the Regeneration of Chondral Tissue. Chapter 15 The Secretome of Mesenchymal Stromal Cells in Treating Intracerebral Hemorrhage: Our Experience. Chapter 16 Stem Cell Secretome as Theranostics for Traumatic Brain Injury. Chapter 17 Cell-Free and Cell-Based Therapies in Regenerative Medicine. Chapter 18 Mesenchymal Stem Cell Secretomes for Cell-Free Therapy of the Broken Heart. Chapter 19 From 2D to 3D and Cellular to Cell-Free: Evolutions in Strategies for Regenerative Medicine. Chapter 20 Cell-Free and Cell-Based Approaches in Neurological Surgery. Chapter 21 A Clinical Overview of Cell-Free and Cell-Based Therapies in Regenerative Medicine. Chapter 22 Autologous versus Allogenic Mesenchymal Stem Cells in Heart Disease: Revisiting Preclinical and Clinical Trials. Chapter 23 Exosomes and Encapsulated ExomiRs in Breast Cancer: Theragnostic Applications and Clinical Implications. Chapter 24 The Potential of Mesenchymal Stem Cell-Derived Exosomes in Cell-Free Therapy for Myocardial Repair. Chapter 25 Theragnostic Applications of Exosomes in Alzheimer's Disease. Index.
