Full Description
Alzheimer's disease continues to present one of the foremost scientific and clinical challenges in contemporary neuroscience. Despite significant advances in molecular biology and neuroimaging, its complex etiology and progressive course remain only partially understood, and truly effective disease-modifying therapies remain elusive.
This scholarly volume offers a comprehensive and integrative examination of Alzheimer's disease, combining cutting-edge research with clinical perspectives. Alzheimer's Disease: Diagnosis, Molecular Targets, and Therapeutic Modalities assembles contributions from leading experts, providing in-depth analysis across a wide range of critical topics:
Innovative diagnostic biomarkers for early detection, prognosis, and therapeutic monitoring
Exploration of molecular targets including secretases, SIRT2, RAGE, calpain, caspases, NMDA receptors, and others implicated in AD pathophysiology
Emerging therapeutic interventions encompassing enzyme inhibitors, immunotherapeutic strategies, metal chelation, neurotrophic modulation, and aggregation inhibitors
Advances in translational research featuring nanotechnology-based delivery systems and bioactive natural compounds
Evidence-based lifestyle interventions integrating nutrition and physical activity in disease management
Spanning 21 rigorously curated chapters, this volume offers a multidisciplinary framework that bridges fundamental research, translational applications, and clinical relevance. It is an essential reference for neuroscientists, clinical researchers, pharmacologists, graduate students, and healthcare professionals engaged in the investigation and management of neurodegenerative disorders.
By synthesizing current scientific knowledge with emerging therapeutic strategies, this volume aims to advance understanding and stimulate further research toward effective interventions for Alzheimer's disease.
Contents
1. Understanding Alzheimer's Disease: An Introduction, Pathophysiology, and Diagnosis 2. Alzheimer's Disease: The Role of Blood Brain Barrier and Strategy to Cross BBB 3. The Application of Vaccines in Alzheimer's Disease: Active and Passive Immunotherapies 4. Secretase-Related Interventions in Alzheimer's: α, β, γ-Secretase, γ-Secretase Inhibitors (GSIs), γ-Secretase Modulators (GSMs) and Natural Products as GSMs 5. A Potential Modulator in Alzheimer's Disease: SIRT2 Inhibitors 6. Therapeutic Potential of Caspase Inhibitors in Alzheimer's Disease 7. Calpain Inhibitors: A Promising Therapeutic Approach in Alzheimer's Disease 8. Acetylcholinesterase Inhibitors: A Viable Therapeutic Strategy for Alzheimer's Disease 9. Noncompetitive N-Methyl-D-Aspartate (NMDA) Antagonist for Prospective Alzheimer's Disease Treatments 10. Phosphodiesterase Inhibitors: A Promising Avenue for Modulating Cognitive Dysfunction in Alzheimer's Disease 11. Autophagy Enhancer: A Promising Therapeutic Approach for Alzheimer's Treatment 12. Therapeutic Potential of Receptor for Advanced Glycation End-Products (RAGE) Inhibitors in the Treatment of Alzheimer's Disease 13. Targeting Alzheimer's Disease Using Neurotrophic Agents and Mimetics: Current Strategies and Challenges 14. Metal Chelators: A Promising Avenue for the Development of Novel Therapeutics for Alzheimer's Disease 15. Apolipoprotein E Based Treatment Approach for Genetically High-Risk Alzheimer's Patients 16. Biomarkers: Diagnostic, Prognostic and Therapeutic Monitoring of Alzheimer's Disease 17. Non-Peptidic Anti-Aggregate Compounds: A Promising Avenue for Alzheimer's Disease Therapy 18. Translational Potentials of Nanotechnology-Based Interventions for Alzheimer's Disease 19. Target of the Neurodegenerative Diseases and Mechanism of the Potent Natural Molecule 20. Therapeutic Nutrition Strategies in Alzheimer's Disease 21. The Role and Importance of Exercise in Alzheimer's Disease
