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Full Description
Proteins: Concepts in Biochemistry teaches the biochemical concepts underlying protein structure, evolution, stability, folding, and enzyme kinetics, and explains how interactions in macromolecular structures determine protein function. Intended for a one-semester course in biochemistry or biophysical chemistry with a focus on proteins, this textbook emphasizes the logic underlying biophysical chemical principles.
Problems throughout the book encourage statistical and quantitative thinking. The text is ideal for senior undergraduates, first-year graduate students, and practitioners in chemistry, biochemistry, biology and biophysics.
Key Features:
Focuses on the interdisciplinary aspect of protein biophysical chemistry, offering a quantitative description of proteins that integrates concepts from organic chemistry, physical chemistry and biology
Written in consideration of the requirements for an ACS-certified BS degree in chemistry, the text meets the recommendations of the American Chemical Society, National Research Council, and National Science Foundation to feature more biochemistry and quantitative study in the life sciences
Each chapter ends with problem sets, with a complete solutions manual available to instructors, and key references for further reading
Contents
1.Statistical Thermodynamics of Biological Molecules
2.Protein Structure
3.Evolution of Protein Sequence and Structure
4.Protein Stability
5.Protein Folding
6.Binding, Allostery, and Cooperativity
7.Enzyme Kinetics
Appendix A. Calculation of the excess heat capacity curve of protein thermal denaturation
Appendix B. Calculation of the average helicity from the partition function
Appendix C. Solution of rate equations for two-state system
Appendix D.Steady-State Rates of Complex Enzyme Reactions
