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Full Description
Completely revised and updated, this fourth edition elucidates the principles of pharmaceutics, biopharmaceutics, dosage form design, and drug delivery - including emerging new biotechnology-based treatment modalities. The authors integrate aspects of physical pharmacy, chemistry, biology, and biopharmaceutics into drug delivery.
With the expiration of older patents and generic competition, the biopharmaceutical industry is evolving faster than ever. Consequently, this edition of the book emphasizes the heightened focus that the recent remarkable progress in gene editing, immunotherapy, and nanotechnology has brought to the design of new drugs and diagnostic approaches along with novel dosage forms.
Apart from new chapters, this edition highlights the emerging emphasis on the role of artificial intelligence (AI) in drug discovery, mRNA and antibody-based therapies, genome editing, immunotherapy, chemical kinetics, and the stability of drug products.
Features:
· Includes new chapters on antibody therapeutics, gene editing, and immunotherapy.
· Explains newer approaches and future methods and the significance of artificial intelligence (AI) in drug discovery.
· Updated sections on pharmacy mathematics, chemical kinetics, and the stability of medicinal products.
· Important updates on parenteral drug products, protein and peptide treatments, and biotechnology-based pharmaceuticals to provide a contemporary perspective on drug development, delivery, and pharmaceutical sciences.
· Expansion of review questions and answers to clarify concepts for students and add to their grasp of key concepts covered in this book.
Although there are numerous books on pharmaceutics and dosage forms, most cover different areas of the discipline and do not provide an integrated approach. The integrated approach of this book not only provides a singular perspective of the overall field, but also supplies a unified source of information for students, instructors, and professionals, saving their time and money.
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Contents
Section I. Introduction
1. Drug discovery
2. Drug Development
3. Pharmaceutical Considerations
4. Biopharmaceutical Considerations
5. Pharmacy Math and Statistics
Section II. Physicochemical Principles
6. Complexation and Protein Binding
7. Chemical Kinetics and Stability
8. Interfacial Phenomena
9. Colloidal Dispersion
10. Surfactants and Micelles
11. Pharmaceutical Polymers
12. Rheology
13. Radiopharmaceuticals
14. Drug Delivery Systems
15. Organ-specific drug delivery
Section III. Dosage Forms
16. Suspensions
17. Emulsions
18. Pharmaceutical Solutions
19. Powders and Granules
20. Tablets
21. Capsules
22. Parenteral Dosage Forms
23. Semisolid Dosage Forms
24. Inserts, Implants, and Devices
Section IV. Pharmaceutical Biotechnology
25. Protein- and Peptide-Based Dosage Forms
26. Antibody Therapeutics
27. Biotechnology-Based Dosage Forms
28. Genome editing technologies
29. Immunotherapy
30. Answers
31. Index
