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Full Description
This comprehensive reference book covers non-shivering thermogenesis, metabolic rates, and associated diseases. It emphasizes the phylogenetic relations of vertebrate non-shivering thermogenesis (NST) and its evolutionary significance. The book describes how the incidence of metabolic syndromes has reached epidemic levels worldwide due to dysregulation in energy balance. Chapters include the evolution and regulatory mechanisms of NSTs. It covers the role of NST in birds and wild animals, and muscle adaptation during hibernation. The book is meant for researchers and students of biochemistry, molecular medicine, and physiology. It is also useful to physicians and health care professionals.
Key Features:
Provides in-depth insights on topics related to metabolic rate regulation and thermogenesis
Covers the evolution of tachymetabolism and endothermy among vertebrates
Analyzes the evolutionary perspectives of non-shivering thermogenesis in different organisms
Discusses the evolution of brown adipose tissue and non-shivering thermogenesis in mammals
Provides graphs, flowcharts, and descriptive figures for easy understanding of concepts
Contents
Unit 1: NONSHIVERING THERMOGENESIS THROUGH BROWN FAT AND ALLIED MECHANISMS. 1. Evolutionary and developmental origin of brown adipose tissue. 2.Molecular mechanisms of heat production in brown adipose tissue. 3.Neurohormonal regulation of heat production in brown adipose tissue. 4.Thermogenic Determinants in Hibernation Models. Unit 2: SKELETAL MUSCLE NONSHIVERING THERMOGENESIS: EVOLUTIONARY, MECHANISTIC AND ECOLOGICAL ASPECTS. 5. Endothermy in Fishes: A Remarkable Story of Convergent Evolutionary Adaptation. 6. Whole-body endothermy and non-shivering thermogenesis (NST) in today's birds and mammals and in their past. 7. Non-shivering thermogenesis in birds: A role for skeletal muscle. 8. Ryanodine Receptor 1 calcium leak in non-shivering thermogenesis. 9. Futile SERCA-mediated calcium cycling activity as the basis for non-shivering thermogenesis in the skeletal muscle. 10.Recruitment of non-shivering thermogenesis in skeletal muscle: Importance of environmental context. Unit 3: BIOMEDICAL RELEVANCE OF NONSHIVERING THERMOGENESIS. 11. Targeting mitochondrial energy efficiency to treat chronic metabolic diseases. 12. Muscle-based thermogenesis and its physiological implications for obesity and muscle health. 13. Recruitment of brown and beige adipose tissue thermogenesis through muscular activity. 14. Phytochemicals as potential candidates to combat obesity via non-shivering thermogenesis.
