Full Description
The Handbook of Neurophotonics provides a dedicated overview of neurophotonics, covering the use of advanced optical technologies to record, stimulate, and control the activity of the brain, yielding new insight and advantages over conventional tools due to the adaptability and non-invasive nature of light.
Including 30 colour figures, this book addresses functional studies of neurovascular signaling, metabolism, electrical excitation, and hemodynamics, as well as clinical applications for imaging and manipulating brain structure and function. The unifying theme throughout is not only to highlight the technology, but to show how these novel methods are becoming critical to breakthroughs that will lead to advances in our ability to manage and treat human diseases of the brain.
Key Features:
Provides the first dedicated book on state-of-the-art optical techniques for sensing and imaging across at the cellular, molecular, network, and whole brain levels.
Highlights how the methods are used for measurement, control, and tracking of molecular events in live neuronal cells, both in basic research and clinical practice.
Covers the entire spectrum of approaches, from optogenetics to functional methods, photostimulation, optical dissection, multiscale imaging, microscopy, and structural imaging.
Includes chapters that show use of voltage-sensitive dye imaging, hemodynamic imaging, multiphoton imaging, temporal multiplexing, multiplane microscopy, optoacoustic imaging, near-infrared spectroscopy, and miniature neuroimaging devices to track cortical brain activity.
Contents
Contents
Preface, ix
Contributors, xi
Part I Function and Structural Neurophotonic Imaging
Chapter 1 ¿ Miniaturized Optical Neuroimaging Systems 3
Hang Yu, Janaka Senarathna, Betty M. Tyler, Nitis h V. Thakor, and Arvi nd P. Pathak
Chapter 2 ¿ Functional Imaging with Light-Sheet Microscopy 21
Raghav K. Chhetri and Philipp J. Keller
Chapter 3 ¿ Two-Photon Microscopy in the Mammalian Brain 55
Hod Dana and Shy Shoham
Chapter 4 ¿ Light Field Microscopy for In Vivo Ca2+ Imaging 81
Tobi as Nöbauer and Alip asha Vaziri
Chapter 5 ¿ Genetically Encoded Activity Indicators 113
Chenchen Song and Thomas Knöpfel
Chapter 6 ¿ Functional Optoacoustic Imaging 129
Daniel Razansky
Chapter 7 ¿ Imaging Deep in the Brain with Wavefront Engineering 147
Roarke Horstmeyer, Maximi llian Hoffmann, Haowen Ruan, Benjami n Judkewitz,
and Changhuei Yang
Chapter 8 ¿ Nanoscopic Imaging to Understand Synaptic Function 173
Daniel Choquet and Anne-Sophie Hafner
Chapter 9 ¿ Chemical Clearing of Brains 191
Klaus Becker, Chris tian Hahn, Nina Jährling, Marko Pende,
Inna Sabdyusheva-Litsc hauer, Saiedeh Saghafi, Martina Wanis , and Hans-Ulric h Dodt
Chapter 10 ¿ Advanced Light-Sheet Microscopy to Explore Brain
Structure on an Organ-Wide Scale 221
Ludovic o Silvestri and Francesc o S. Pavone
Part II Neurophotonic Control and Perturbation
Chapter 11 ¿ Optogenetic Modulation of Neural Circuits 235
Mathias Mahn, Oded Klavi r, and Ofer Yizhar
Chapter 12 ¿ Molecular Photoswitches for Synthetic Optogenetics 271
Shai Berlin and Ehud Y. Isacoff
Chapter 13 ¿ Applications of Nanoparticles for Optical Modulation of
Neuronal Behavior 293
Chiara Pavi olo, Shaun Gietman, Daniela Duc, Sim on E. Moulton, and
Paul R. Stoddart
Chapter 14 ¿ Optical Stimulation of Neural Circuits in Freely Moving
Animals 317
Leore R. Heim and Eran Stark
Chapter 15 ¿ Holographic Optical Neural Interfaces (HONIs) 333
Shani Rosen, Shir Paluch, and Shy Shoham
Chapter 16 ¿ Multi-Photon Nanosurgery 353
Anna Letizia Allegra Masc aro and Francesc o Saverio Pavone
Part III Clinical and Human Neurophotonics
Chapter 17 ¿ High Resolution Diffuse Optical Tomography of the
Human Brain 369
Muriah D. Wheelock and Adam T. Eggebrecht
Chapter 18 ¿ Human Brain Imaging by Optical Coherence Tomography 399
Caroline Magnain, Jean C. Augustinack, Davi d Boas, Bruce Fisc hl, Taner Akkin,
Ender Konukoglu, and Hui Wang
Chapter 19 ¿ Acousto-Optic Cerebral Monitoring 439
Mic hal Balberg and Revi tal Pery-Shechter
Chapter 20 ¿ Neurophotonic Vision Restoration 459
Adi Schejter Bar-Noam and Shy Shoham
Chapter 21 ¿ Optical Cochlear Implants 473
C.-P. Ric hter, Y. Xu, X. Tan, N. Xia, and N. Suematsu
Chapter 22 ¿ Label-Free Fluorescence Interrogation of Brain Tumors 503
Brad A. Hartl, Shami ra Sridharan, and Laura Marcu
Chapter 23 ¿ Higher Harmonic Generation Imaging for Neuropathology 527
Nikolay Kuzmi n, Sander Idema, Eleonora Aronic a, Philip C. de Witt Hamer,
Pieter Wess eling, and Marie Louis e Groot
INDEX, 545
