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Full Description
A biofilm is a collection of microbial cells that have adhered to biotic surfaces such as plant cuticles or animal epithelia, as well as abiotic surfaces such as rocky substratum or catheter exteriors. The life cycle of a microorganism includes the fundamental process of biofilm formation for survival in diverse and harsh environments since it is a protected mode of growth allowing colonisation of new habitats by dispersal of microbes from the microbial clusters. The biofilm bound microorganisms remain embedded in an extracellular polymeric matrix that protects the indwelling cells from surfactants, biocides, several invaders like protozoans, and defences offered by the hosts like phagocytic cells. The biofilm bound recalcitrant microbes induce chronic and nosocomial diseases, posing a serious threat to public health. It has been observed that various antimicrobial drugs are able to successfully remove the planktonic (freely suspended) states of microbes as compared to the sessile (substrate-bound) forms, thus resulting in the development of antimicrobial resistance.
Modern pharmacological strategies targeting the biofilm matrix differ from the conventional methods of antibiotic usage. This includes the use of natural compounds such as plant bioactive molecules, antimicrobial peptides, green synthesised nanoparticles, or secondary metabolites from other organisms that not only prevent the rise of antimicrobial resistance but are also safe for the host tissues.
Biofilm Associated Antimicrobial Resistance and Its Recovery provides a detailed and systematic review of alternative pharmacological developments in the field of biofilm research.
Features:
A narrative overview of the mechanism of biofilm formation and its role in the emergence of antimicrobial resistance
Recent research in the development of antibiofilm remedies involving biogenic compounds
Advancements in biofilm detection methodologies with cutting-edge technologies
This book serves as a resource for researchers who need to understand and analyze the progression of events during microbial biofilm formation, as well as design safer methodologies for its successful eradication. It may also be used as a textbook for a graduate level course in microbiology or microbial biotechnology.
Contents
Introduction
Biofilm Formation and Metabolomic Regulation
Susceptibility Testing for the Determination of Biofilm Associated Resistance
Nutritional and Stress Responses Resulting in the Development of AMR
Efflux Pumps and Their Role in the Development of Resistance in Biofilm
Genetic Diversity Resulting in the Development of AMR
Multispecies Interactions Resulting in the Development of Antimicrobial Resistance
Nanotechnology Approaches to Treating Antimicrobial Resistant Infections Caused by Biofilms: Research Needs for Translation from In Vitro to In Vivo Applications
Antimicrobial Peptides for Treating Biofilm Associated Infections
Enzymatic Dispersion of Biofilms: Applications, Challenges and Quantification
CRISPR/Cas Therapeutics in the Inhibition of Biofilm
Small Molecule Associated Inhibition of Metabolic Pathways in Biofilm
Bacteriophage Associated Inhibition of Biofilm: A Review
Nanoparticle Associated Inhibition of Biofilm
Biofilms: Formation, Regulation, and Detection
