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Full Description
Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book.
Key Features
Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction.
Includes summary of both causes and effects of these diseases.
Discusses current and potential future therapies for mitochondrial dysfunction diseases
Explores a wide variety of diseases caused by dysfunctional mitochondria.
Contents
Preface ........................................................................................................................................................................... xi
Acknowledgment......................................................................................................................................................... xiii
About the Editor .......................................................................................................................................................... xv
Contributors ............................................................................................................................................................... xvii
SECTION I Introduction: Structure and Function of Mitochondria
Chapter 1 Mitochondrial Structure and Function ....................................................................................................... 3
Marcos Roberto de Oliveira
Chapter 2 Structure, Function and Evolutionary Aspects of Mitochondria ................................................................ 9
Puja Agarwal, Mehali Mitra, and Sujit Roy
Chapter 3 Mitochondrial Genome Damage, Dysfunction and Repair ........................................................................23
Kalyan Mahapatra, Sayanti De, and Sujit Roy
SECTION II Mitochondrial Dysfunction and Diseases
Chapter 4 Instability of Human Mitochondrial DNA, Nuclear Genes and Diseases ..................................................39
Katarzyna To?ska
Chapter 5 Kearns-Sayre Syndrome .............................................................................................................................55
Josef Finsterer
Chapter 6 Mitochondrial Dysfunction and Barth Syndrome......................................................................................61
Arianna F. Anzm
