Full Description
Diets rich in plant polyphenols or dietary polyphenols are the subject of increasing scientific interest because of their diverse range of health benefits and medicinal uses. This book, Dietary Polyphenols in Human Diseases: Advances and Challenges in Drug Discovery, fills the gap that exists in the current knowledge by presenting the latest information in the area of polyphenol-based drug discovery research. The book focuses on the current understanding of the beneficial effects on human health of diets rich in polyphenols and/or polyphenolic compounds derived from dietary sources (plant-based foods) and their possible preventive role in the management of chronic human diseases. In addition, biochemical mechanisms involved in the antioxidative effect of dietary polyphenols along with their bioavailability, pharmacokinetic, and toxicological considerations are also discussed herein.
Key Features
Presents health benefits and medicinal importance of dietary polyphenols having antioxidative effects and their possible preventive role against oxidative stress (OS)-induced chronic human diseases.
Summarizes the latest understanding of the biochemical mechanism(s) involved in the antioxidative action of dietary polyphenols along with their bioavailability, pharmacokinetic, and toxicological considerations.
Highlights novel approaches of drug discovery from dietary polyphenols through computational screening of bioactive phytochemical components.
With contributions by a global team of experts (academics, scientists, and researchers), this book is intended to be a useful resource for a wider audience, particularly those working in the area of drug discovery and development research, such as discovery scientists, pharmaceutical scientists (R&D), formulation scientists, medicinal chemists, pharmacologists, toxicologists, phytochemists, biochemists, clinicians, researchers, students, teachers, and many others.
Contents
Chapter 1: Dietary polyphenols, antioxidant effects and human diseases
Chapter 2: Biochemical, molecular, pharmacokinetic and toxicological aspects of dietary polyphenols
Chapter 3: Dietary polyphenols in aging, neurological and cognitive disorders
Chapter 4: Dietary polyphenols in cancer
Chapter 5: Dietary polyphenols in cardiovascular diseases (CVDs)
Chapter 6: Dietary polyphenols in arthritis and inflammatory disorders
Chapter 7: Dietary polyphenols in diabetes
Chapter 8: Dietary polyphenols in bacterial and fungal infections
Chapter 9: Dietary polyphenols in viral infections
Chapter 10: Dietary polyphenols in parasitic diseases and neglected tropical diseases (NTDs)
Chapter 11: Dietary polyphenols for the management of skin diseases and wound healing
Chapter 12: Dietary polyphenols from spice and their impact on human health
Chapter 13: Dietary polyphenols in drug discovery by drug repurposing and computational screening
