Full Description
Brain maldevelopment or injury in utero can cause life-long disability. Focussing on improvements in imaging methods, therapeutics, and perinatal care that can help to identify, prevent, or treat brain problems in the fetus and newborn, this new edition brings the reader fully up to date with recent advances in clinical management and outcome assessment. Updated material includes protective strategies for pre-term and term infants, ways of promoting of brain development in the neonatal intensive care unit, resuscitation, and immediate care after resuscitation (golden hour care), and parental perspectives, particularly strategies for communicating with families. An outstanding international team of highly experienced neonatologists and maternal-fetal medicine clinicians have produced a practical and authoritative clinical text offering clear management advice to all clinicians involved in the treatment of the fetus and newborn.
Contents
Preface; Section 1. Epidemiology, Pathophysiology, and Pathogenesis of Fetal and Neonatal Brain Injury: 1. Epidemiology, pathophysiology, and pathogenesis of fetal and neonatal brain injury and encephalopathy Jeffrey M. Perlman; 2. Neuronal cell death, connectomics, and proteinopathy in human neonatal hypoxic-ischemic encephalopathy and related animal models Lee J. Martin, Frances J. Northington, Jennifer K. Lee and Panagiotis Kratimenos; 3. Cellular and molecular biology of hypoxic-ischemic encephalopathy Fernando F. Gonzalez, Zinaida S. Vexler and Donna M. Ferriero; 4. The pathogenesis of preterm brain injury Justin Mark Dean, Benjamin Alan Lear, Laura Bennet and Alistair Jan Gunn; 5. Fetal responses to hypoxemia and asphyxia Laura Bennet, Christopher A. Lear, Guido Wassink and Alistair Jan Gunn; 6. Endogenous and exogenous neuroprotective mechanisms after hypoxic-ischemic injury Joanne O. Davidson, Simerdeep K. Dhillon, Laura Bennet and Alistair Jan Gunn; Section 2. Pregnancy, Labor, and Delivery Complications Causing Brain Injury: 7. Prematurity and complications of labor and delivery Hayley E. Miller and Danielle M. Panelli; 8. Risks and complications of multiple gestation Kathleen Minor, Samantha Do and Yair J. Blumenfeld; 9. Intrauterine growth restriction William W. Hay Jr., Ronald J. Wong and David K. Stevenson; 10. Diseases in pregnancy that affect fetal and neonatal neurodevelopment Anne R. Waldrop and Maurice L. Druzin; 11. Obstetric conditions and practices that affect the fetus and newborn Noor Joudi, Erica Wu and Jane Chueh; 12. Consequences of fetal substance exposure Robert Castro, Gary M. Shaw and Ronald S. Cohen; 13. Hypertensive disorders of pregnancy Christina Pinnock, Maurice L. Druzin and Deirdre J. Lyell; 14. Complications of Labor and Delivery Kathryne Sanserino, Erica Wu, Samantha Do and Yair J. Blumenfeld; 15. Antepartum evaluation of fetal well-being Nicola C. Perlman, Deirdre J. Lyell and Maurice L. Druzin; 16. Intrapartum evaluation of the fetus Liron Seidman, Israel Hendler, Daniel S. Seidman and Abraham Tsur; Section 3. Diagnosis of the Infant with Brain Injury: 17. Clinical manifestations of hypoxic-ischemic encephalopathy Amanda G. Sandoval Karamian and Tayyba Anwar; 18. The use of EEG and aEEG in assessing the term and preterm brain Kristine E. Woodward and Julia Jacobs-LeVan; 19. Neuroimaging in the evaluation of pattern and timing of fetal and neonatal brain abnormalities Bruno P. Soares and Mateus A. Esmeraldo; 20. Near-infrared spectroscopy monitoring of the brain Valerie Y. Chock and Zachary A. Vesoulis; 21. Placental pathology and the etiology of fetal and neonatal brain injury Charlotte Foster Kim and Theonia K. Boyd; 22. Timing perinatal hypoxic-ischemic brain injury Simerdeep K. Dhillon, Joanne O. Davidson, Laura Bennet and Alistair Jan Gunn; Section 4. Specific Conditions Associated with Fetal and Neonatal Brain Injury: 23. Congenital malformations of the brain Andrerw Campion, Bruno P Soares and Hisham Dahmoush; 24. Neurogenetic disorders of the brain Courney P. Verscaj, Jonathon A. Bernstein; 25. Hemorrhagic lesions of the central nervous system Mehmet N. Cizmeci and Linda S. de Vries; 26. Perinatal stroke Dawn Gano and Donna M. Ferriero; 27. Neurodevelopmental consequences of neonatal hypoglycemia Elizabeth Rosenfeld and Diva D. De León; 28. Hyperbilirubinemia and kernicterus David K. Stevenson, Cody C. Arnold, Phyllis A. Dennery and Ronald J. Wong; 29. Polycythemia and fetal-maternal bleeding Ted S. Rosenkrantz, Shikha Sarkar and William Oh; 30. Hydrops fetalis Carlo Bellini, Dario Paladini and Luca A. Ramenghi; 31. Brain injury caused by activation of the immune system Isabelle Shearer, Pierre Gressens and Bobbi Fleiss; 32. Neonatal bacterial meningitis Dustin Daniel Flannery, Alvaro Proaño FanconiI and Lakshmi Srinivasan; 33. Neurologic sequelae of congenital and perin
