Full Description
The idea that the adult brain of mammals can generate new neurons has only recently been accepted by the scientific community, and research in this exciting area is now in full swing. Bringing together leading researchers in the field of adult neurogenesis, the 30 chapters in this monograph provide a valuable overview of this emerging field and lay the groundwork for future studies. Adult Neurogenesis includes discussions on neural stem cell biology; methods and models for studying adult neurogenesis; physiological and molecular processes and their control; related neurological diseases; and comparisons of neurogenesis in humans, birds, fish, and invertebrates. It will be of interest to all researchers in neurobiology as well as those in the medical field, as it has implications for understanding depression, epilepsy, and other psychiatric disorders.
Contents
Contents: 1. Adult Neurogenesis: A Prologue (F.H. Gage, H. Song, and G. Kempermann) METHODS In vivo approaches 2. Numerology of Neurogenesis: Characterizing the Cell Cycle of Neurostem Cells (R.S. Nowakowski and N.L. Hayes) 3. Detection and Phenotypic Characterization of Adult Neurogenesis (H.G. Kuhn and D.A. Peterson) 4. Evolving Methods for the Labeling and Mutation of Postnatal Neuronal Precursor Cells: A Critical Review (J.J. Breunig, J. D. Macklis, and P.R. Rakic) 5. The Use of Reporter Mouse Lines to Study Adult Neurogenesis (G. Enikolopov and L. Overstreet-Wadiche) 6. Retrovirus-mediated Cell Labeling (C. Zhao) In vitro approaches 7. Neurospheres (I. Singec and A. Qui f1;ones-Hinojosa) 8. Monolayer Cultures of Neuronal Stem/Progenitor Cells (J. Ray) BASIC PROCESSES 9. Neurogenesis in the Adult Hippocampus (G. Kempermann, H. Song, and F.H. Gage) 10. Adult Subventricular Zone and Olfactory Bulb Neurogenesis (D.A. Lim, Y.-C. Huang, and A. Alvarez-Buylla) 11. Neurogenic Niches in the Adult Mammalian Brain (D.K. Ma, G.-l. Ming, F.H. Gage, and H. Song) MOLECULAR AND PHYSIOLOGICAL MECHANISMS 12. Adult Neurogenesis: Similarities and Differences in Stem Cell Fate, Proliferation, Migration, and Differentiation in Distinct Forebrain Regions (D.C. Lie and M. G f6;tz) 13. Proneuronal Genes Drive Neurogenesis on the Road from Development to Adulthood (E.T. Buchen and S.J. Pleasure) 14. The Balance of Trophic Support and Cell Death in Adult Neurogenesis (H.G. Kuhn) 15. Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus (J. Bischofberger and A.F. Schinder) REGULATION 16. Genetics and Epigenetics in Adult Neurogenesis (J. Hsieh and J.W. Schneider) 17. Activity Dependency and Aging in the Regulation of Adult Neurogenesis (G. Kempermann) 18. Regulation of Hippocampal Neurogenesis by Systemic Factors Including Stress, Glucocorticoids, Sleep, and Inflammation (P.J. Lucassen, C.A. Oomen, A.-M. van Dam, and B. Cz e9;h) 19. Regulation of Adult Neurogenesis by Neurotransmitters (M.-H. Jang, H. Song, and G.-l Ming) FUNCTIONAL SIGNIFICANCE 20. Adult Neurogenesis in the Olfactory Bulb (P.-M. Lledo) 21. Neurogenesis and Hippocampal Memory System (D.N. Abrous and J.M. Wojtowicz) 22. Computational Modeling of Adult Neurogenesis (J.B. Aimone and L. Wiskott) NEUROLOGICAL DISEASES 23. Hippocampal Neurogenesis: Depression and Antidepressant Responses (A. Sahay, R. Hen, and R.S. Duman) 24. Adult Neurogenesis in Neurodegenerative Diseases (P. Brundin, J. Winkler, and E. Masliah) 25. Epilepsy and Adult Neurogenesis (S. Jessberger and J.M. Parent) 26. Neurogenesis Following Stroke Affecting the Adult Brain (O. Lindvall and Z. Kokaia) COMPARATIVE NEUROGENESIS 27. Adult Neurogenesis in Teleost Fish (G.K.H. Zupanc) 28. Neurogenesis in the Adult Songbird: A Model for Inducible Striatal Neuronal Addition (S.A. Goldman) 29. Adult Human Neurogenesis: A Response to Cell Loss and New Circuitry Requirements (M.A. Curtis, P.S. Eriksson, and R.L.M. Faull) 30. Adult Hippocampal Neurogenesis in Natural Populations of Mammals (I. Amrein, H.-P. Lipp, R. Boonstra, and J.M. Wojtowicz) Index
