Full Description
Innovative Leukemia and Lymphoma Therapy provides a complete and up-to-date overview of the exciting new treatment modalities in leukemia and lymphoma that are being introduced in the clinic today. Written by international experts in the field, this volume examines clinical studies on topics such as:
tyrosine kinase inhibitors, histon deacetylase inhibitors, and farnesyl transferase inhibitors
radioimmunotherapy, gene-directed therapy, and immunotherapy by vaccination
monoclonal antibodies
anti-angiogenesis approaches
Within each chapter, this well-illustrated, comprehensive source provides a summary of the rationale for treatment, the pathways that are involved, and the translational research to students, scientists, and clinicians. In addition, this book focuses on the concerns of conventional but novel anticancer agents, modulation of classical multidrug resistance, and modulators of single agent drug resistance.
Contents
Foreword, Preface, Contributors, 1. Gene Expression Profiling to Detect New Treatment Targets in Leukemia and Lymphoma: A Future Perspective, 2. Individualized Tumor Response Testing in Leukemia and Lymphoma, 3. Minimal Residual Disease, 4. New Methods for Clinical Trials: AML as an Example, 5. Monoclonal Antibody Mediated Treatment in Acute Myeloid Leukemia, 6. Monoclonal Antibodies in the Treatment of Malignant Lymphomas and Chronic Lymphocytic Leukemia, 7. Radioimmunotherapy of Hematological Malignancies, 8. Differentiation Induction in Acute Promyelocytic Leukemia, 9. DNA Methylation and Epigenetics: New Developments in Biology and Treatment, 10. The Emerging Role of Histone Deacetylase Inhibitors in the Treatment of Lymphoma, 11. Antileukemic Treatment Targeted at Apoptosis Regulators, 12. Angiogenesis in Hematological Malignancies, 13. Nucleic Acid-Based, mRNA-Targeted Therapeutics for Hematologic Malignancies, 14. Active Specific Immunization by the Use of Leukemic Dendritic Cell Vaccines, 15. CDK Inhibitors in Leukemia and Lymphoma, 16. FLT3: A Receptor Tyrosine Kinase Target in Adult and Pediatric AML, 17. Treatment of Chronic Myeloid Leukemia with Bcr-Abl Kinase Inhibitors, 18. Tyrosine Kinase Inhibitors: Targets Other Than FLT3, BCR-ABL, and c-KIT, 19. Tyrosine Phosphatases as New Treatment Targets in Acute Myeloid Leukemia, 20. Proteasome and Protease Inhibitors, 21. Farnesyltransferase Inhibitors: Current and Prospective Development for Hematologic Malignancies, 22. Targeting Notch Pathways, 23. mTOR Targeting Agents for the Treatment of Lymphoma and Leukemia, 24. Allogeneic Hematopoietic Cell Transplantation After Nonmyeloablative Conditioning, 25. Modulation of Classical Multidrug Resistance and Drug Resistance in General, Index
