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基本説明
An ideal text for graduate courses in cancer, this book covers: organic and metal carcinogenesis related to lung, breast, prostate, skin, liver, colon, brain, and thyroid cancers; the human implications of data regarding oncogenesis of transgenic and knockout mice and rats; and more.
Full Description
To gain a complete overview of what is presently known about molecular carcinogenesis would prove to be a very daunting task for those not already steeped in this complex subject. Fortunately, David Warshawsky and Joseph Landolph Jr., both highly respected for their own contributions to the field, know exactly whom to call upon to fulfill the need for a definitive summary.
Molecular Carcinogenesis and the Molecular Biology of Human Cancer provides a technical, as well as historical, overview of research covering the science of cancer. This volume explores molecular information specific to chemical, viral, and radiation carcinogenesis, explains the working of cellular oncogenes and tumor suppressor genes, and also introduces readers to the latest genomic and proteomic approaches.
The first part of the book offers basic information; the second part deals strictly with cancer in humans. It commences with discussions on induction and exposure, then reviews complex mixtures of chemical carcinogens, and provides several chapters on tumors, organized by specific organs.
This section also covers chemoprevention of chemical carcinogenesis, exposure assessment, and biomarkers, as well as the role of risk assessment, before offering a discussion on prevention that includes the history and particulars of carcinogen regulations.
Featuring leading researchers writing about their areas of expertise, this book provides a succinct yet detailed reference that meets the needs of professional researchers, clinicians, and environmental regulators, as well as attorneys practicing law in the area of toxic torts. Its progressive structure allows it to also serve as a primary text or resource for students in medicine and cancer research.
Contents
Historical Perspective and Overview. Whole Animal Carcinogenecity Bioassays: Initiation and Promotion. Classes of Carcinogens. Metabolic Activation of Chemical Carcinogens. DNA Binding of Carcinogens to DNA and Covalent Adducts and DNA Damage-Mechanisms of Carcinogenesis. Mutagenesis and Genetic Toxicology. Chemically Induced Morphological and Neoplastic Transformation. Viral Carcinogenesis. Oncogene Activation and Chemical Carcinogenesis. Tumor Suppressor Gene Inactivation and Chemical Carcinogenesis. Radiation Carcinogenesis. Overview of Human Cancer Induction and Human Exposure to Carcinogens. Lung Cancer. Skin Cancer. Other Chemically Induced Cancers. Mixtures of Chemical Carcinogens: Principles of Action and Human Exposure. Risk Assessment and Regulation of Carcinogens. Chemoprevention of Chemical Carcinogenesis and Human Cancer.
