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Full Description
Bioinorganic Chemistry: Cellular Systems and Synthetic Models includes chapters describing cutting-edge work by renowned researchers in the field that fall within two main areas of current bioinorganic chemistry: (1) the study of cellular systems and processes that occur inside cells that are impacted by inorganic elements, e.g., biosynthetic pathways leading to the production of vital metal-containing enzymes and proteins including iron-sulfur clusters,
hemes, and cytochrome c oxidase; metal homeostasis (Zn2+ in E. coli); and new strategies to examine DNA targeting by metal-based drugs using, as an example, the clinically-employed bleomycin class of antitumor agents, and (2) sophisticated new inorganic model systems, many of which escape the traditional
approach of trying to use structural mimics of the native systems to produce functional mimics and instead use a more conceptual approach to the use of bioinorganic models to understand the native system or to develop useful synthetic molecules. In the former area, unlike most traditional efforts in bioinorganic chemistry that have been devoted to studies of the structures and functions of metal centers located within individual metal-containing proteins, the topics described in this volume
seek to describe whole systems of interaction between multiple interacting biomolecules that are impacted by inorganic species. In the latter area, along with chapters devoted to more traditional ligand systems and inorganic reactivities, peptide- and protein-like ligand systems are emphasized creating
agents that: lead to novel structures and morphologies, de novo designed systems that model biological Hg binding, and unique DNA-targeted agents that mimic the activities of nucleic acid-targeted natural products and proteins. Together, these chapters provide examples of the exciting current work in two important areas in the exciting field of bioinorganic chemistry.
Contents
PREFACE ; PART I - CELLULAR SYSTEMS ; 1. Iron Sulfur Cluster Biosynthesis: Scaffold and Donor Proteins, and Mechanistic Insights ; 2. Molecular Interaction Between Frataxin and Ferrochelatase During Heme Assembly: Frataxin's Role as a Potential Iron Chaperone During Heme Biosynthesis ; 3. Biosynthesis and Regulation of the Heme: A Biosynthetic Pathway ; 4. Assembly of Cytochrome c Oxidase ; 5. New Approaches to Analyzing the Site Selectivities and Crystal Structures of DNA Targeted Metal Complexes ; 6. Zn(II) Homeostasis in E. coli ; PART II - SYNTHETIC MODELS ; 7. N2S3X-Fe Models of Nitrile Hydratase ; 8. Studies Into the Metal Chemistry of the Carbaporphyrinoids: Insights Into the Biological Choice of Porphyrin ; 9. Bioinspired Aerobic Substrate Oxidation: A Ni(II)-Oximate Catalyst that Parallels Biological Alcohol and Amine Oxidation Chemistry ; 10. Inorganic Models for Two-Electron Redox Chemistry in Biological Systems: Ligand-Bridged Molybdenum and Tungsten Dimers ; 11. Metal-Mediated Peptide Assembly: From Discrete Molecular Species to Large-Scale Morphologies ; 12. Understanding the Biological Chemistry of Mercury Using a de novo Protein Design Strategy ; 13. Understanding Oxotransferase Reactivity in a Model System Using Singular Value Decomposition Analysis ; 14. DNA Minor Groove Recognition by Ni(II)- and Cu(II)-Gly-Gly-His Derived Metallopeptides
