Full Description
Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs provides a one-stop guide to the essential basic and clinical science of all the effective, life-prolonging drug therapies in oncology. From traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents, this book covers the staggering advances in cancer pharmacology that are propelling new standards of care for common and uncommon malignancies. Beautifully illustrated throughout, each chapter contains visually engaging figures detailing the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic, and molecular properties of the various agents, and their mechanisms of action. As the first illustrated book of its kind, this highly visual text uses a uniform approach to each cancer drug class and agent presented in the book, and covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more. Flow diagrams, clinical tables, and bulleted text further explain important information pertaining to each cancer drug class including their indications, mechanisms of action, potential adverse reactions, dosing and dose adjustments, and safety monitoring. Organized in an easyto- digest format and replete with detailed images, clinical pearls, and end of chapter Q&As, this evidence-based reference presents all major classes, agents, targets, and approaches to cancer pharmacotherapy.
Whether you are a trainee, a clinical scientist, or a clinician in practice, the book is an ideal reference. It presents challenging information in an instructional way, illustrates key concepts for ease of retention, and poses tough questions so readers can problem solve potential scenarios and test their pharmacologic acumen. Written by leading experts in oncopharmacology, this first-of-its kind manual is a "must have" for anyone involved in the basic, translational, or clinical aspects of oncology and hematology including clinicians, pharmacists, nurses, and trainees.
KEY FEATURES:Includes visual depictions of chemical structures, pharmacokinetics, pharmacodynamics, and pharmacogenomics associated with each class of agents
Describes how chemotherapy, targeted therapy, immunotherapy, and hormonal therapy work and why they are expected to work adjuvantly, neoadjuvantly, and in combination with other modalities
Over 100 highly stylized images and numerous comprehensive tables
Covers challenges related to drug development, drug approval, and regulatory issues in relation to anticancer treatments
All chapters conclude with clinical pearls and detailed clinical Q&As with descriptive rationales
Purchase includes access to the ebook for use on most mobile devices or computers
Contents
We dedicate this book to the chemists, biologists, pharmacologists, clinicians and clinical investigators, and patients and their families who continue to improve the lives of patients with cancer—and to science and its divinity.
Contents
Contributors
Preface
1. Anticancer Drug Development: An Introduction
2. Alkylating Agents
3. Antimetabolites: Hydroxyurea, Pyrimidine and Purine Analogs, and L-Asparaginase
4. Antimetabolites: Antifolates
5. Antimitotics
6. DNA Repair, Apoptotic Pathways, CDK Inhibitors
7. Epigenetic Modulators
8. Differentiating Agents and Microenvironment
9. Hormonal Therapies Alone and in Combinations for Treatment of Breast Cancer
10. Male Hormonal Therapies
11. Targeted Therapies (Small Molecules)
12. Monoclonal Antibodies Including Immunoconjugates and Cytokine-Directed Agents
13. Immunotherapeutics Including Vaccines, Bispecifics, CAR-T, and Checkpoint Inhibitors
14. Multiple Myeloma as a Paradigm for Multi-Targeted Intervention
15. Transplant-Related Agents
16. Basic Drug Development With Structural Considerations
17. Integral Components in Development of Clinical Trials: PK/PD, Statistics, and Principles of Rational Combinatorial Therapies
18. Drug Approval and Regulatory Issues
Index
Contributors
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