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基本説明
Covers the principles of allosterism in reference to drug action, and progresses to an examination of individual receptor systems including GABA, Serotonin3, Glutamate NMDA and acetylcholine Nicotinc receptors.
Full Description
Offering a wide array of illustrations and tables in every chapter, this book extensively covers the principles of allosterism in reference to drug action and progresses to a detailed examination of individual ionotropic and G-protein coupled receptor systems-helping those new to the subject understand the importance of allosterism and providing those already working in the field with specific reference information. This title provides in-depth chapters on basic principles of allosterism and its significance at GABAA, 5HT3, nicotinic, and GABAB receptors, ionotropic and metabotropic receptors for glutamate, muscarinic receptors and alpha 2 adrenoceptors to provide a firm foundation to the subject.
Contents
BASIC PRINCIPLES. Allosteric Modulation of Receptor Function. Characteristics of Allosterism in Drug Action. Predicting Dose-Response Curve Behavior: Mathematical Models of Allosteric Ligand-Receptor Interactions. IONOTROPIC RECEPTORS. Allosteric Modulation of GABAA Receptors: A Pharmacology of Sleep, Anxiety and Memory. Allosteric Interactions at the NMDA Receptor Channel Complex. 5-HT3 Receptors. Nicotinic Receptors. G-PROTEIN COUPLED RECEPTORS. Allosteric Modulation of G protein-coupled Receptors. Adenosine Receptor. Allosteric Modulators of Group III Metabotropic Glutamate Receptors as Novel Therapeutics. Allosteric Modulation of Gamma-Aminobutyric Acid B (GABAB) Receptors. Allosteric Interactions at GABAB and Related G-Protein-Coupled Receptors. Muscarinic Receptors: Targeting Allosteric Modulation by the Development and Application of the Radiolabeled Allosteric Agent [3H]dimethyl-W84. Alpha 2 Adrenoceptors: Physiology, Pharmacology and Allosteric Modulation.
