Full Description
Blending basic science with the latest clinical insights, this important book presents new ideas on the molecular biology, biochemistry, crystallography, and pharmacology of eicosanoids, including their interaction with antiinflammatory drugs and their influence on the mechanisms of asthma. Surveys a rich panorama of clinical symptoms from the European Network on Aspirin-Induced Asthma, the largest database of its kind in the world! Edited by clinicians with long experience in the field, Eicosanoids, Aspirin, and Asthmaelucidates basic asthma mechanisms such as genetic influences, viruses, ion airway transport, and autoimmunity profiles the effectiveness of corticosteroids and aspirin desensitization in asthma treatment devotes special attention to aspirin-induced asthma reveals new details on the mechanisms of action of anti-inflammatory drugs provides evidence for the pneumoprotective action of endogenous nitric oxide highlights recent applications of crystallography in the understanding of the three-dimensional structure of cyclooxygenase describes new pathways of arachidonic acid metabolism explores the clinical manifestations in aspirin-induced asthma and more! Complete with over 2000 references, Eicosanoids, Aspirin, and Asthma will be welcomed by pulmonologists and pulmonary physicians, pulmonary rehabilitation therapists, respiratory physiologists, immunologists, allergists, pharmacologists, internists, chest physicians, otolaryngologists, pediatricians, molecular and cell biologists, epidemiologists, neuroanatomists, biochemists, and graduate and medical school students in these disciplines.
Contents
Mechanism of Action of Antiinflammatory Drugs, John R. Vane and Regine M. BottingPathways of Arachidonate Metabolism, John C. McGiff and Michael BalazyCytochromes P450 and Arachidonic Acid Metabolism, Michael Balazy and John C. McGiffMechanisms of Isoprostane Biosynthesis in Humans, Paola Patrignani, Roberto Padovano, Maria Gina Sciulli, Giovanna Santini, Maria Rosaria Panara, Maria Teresa Rotondo, Giulia Renda, and Carlo PatronoIntracellular Localization of Eicosanoid-Forming Enzymes, Thomas G. Brock and Marc Peters-GoldenCyclooxygenase-2 Expression in Airway Cells, Peter J. Barnes, Maria G. Belvisi, Robert Newton, and Jane A. MitchellCyclooxygenase Gene Expression and Regulation, Kenneth Kun-yu WuNSAID-Induced Apoptosis: A New Therapeutic Activity of Competitive Cyclooxygenase Inhibitors?, Daniel L. SimmonsThe Three-Dimensional Structure of Cyclooxygenases, Daniel PicotThe Role of 5-Lipoxygenase Products in a Mouse Model of Allergic Airway Inflammation, Colin D. Funk, Xin-Sheng Chen, Charles G. Irvin, Yuan-Po Tu, and James R. ShellerGenetic Influences on Asthma, William O. C. M. CooksonIntrinsic Asthma, Leonardo M. Fabbri, Gaetano Caramori, Bianca Beghe, and Cristina MappViral Infection and Asthma: The Modulatory Role of Nitric Oxide on Prostaglandin H Synthase, Gert Folkerts and Frans P. NijkampThe Pharmacology of Prostaglandin E2: Actions in Human Diseases Involving the Mast Cell, John A. Oates, John J. Murray, David D. Hagaman, James R. Sheller, Ryszard Dworski, and L. Jackson Roberts II, and Howard R. KnappEicosanoids in the Pathogenesis of Exercise- and Allergen-Induced Asthma, Paul M. O'ByrneEndotoxin-Induced Acute Respiratory Distress Syndrome in Nitric Oxide-Deficient Rats, Pawel P. Wolkow, Ewa Janowska, Joanna B. Bartus, Wojciech Uracz, and Ryszard J. GryglewskiEicosanoid Regulation by Glucocorticoids in Asthma, Ryszard DworskiMechanisms of Aspirin-Induced Asthma, Andrzej SzczeklikLeukotrienes in Aspirin-Sensitive Asthma, S. M. Shuaib Nasser and Tak H. LeeMast Cell and Eosinophil Responses After Indomethacin in Asthmatics Tolerant and Intolerant to Aspirin, Esther L. Langmack and Sally E. WenzelAspects of Mechanisms in Aspirin-Intolerant Asthma, Barbro DahlenAspirin-Intolerant Asthma: New Insights from Bronchial Mucosal Biopsies, Anthony P. SampsonPharmacological Intervention in Generation of Leukotrienes by Eosinophils, Klaus F. Rabe and Gordon DentAirway Ion Transport Mechanisms and Aspirin in Asthma, Sebastiano Bianco, Maria Robuschi, Adriano Vaghi, and Piersante SestiniRole of Autoantibodies Against Endothelial Cells in Severe Asthma, Philippe Lassalle, Michel Joseph, and Andre-Bernard TonnelClinical Course of Aspirin-Induced Asthma: Results of AIANE, Ewa Nizankowska, Mariusz Duplaga, Grazyna Bochenek, and Andrzej SzczeklikNasal Polyposis, Niels Mygind, Ronald Dahl, Per L. Larsen, Torben Lildholdt, and Claus BachertThe Nose in Aspirin-Sensitive Asthma, Cesar Picado and Joaquim MullolThe Role of Glucocorticoids in the Modulation of Eicosanoid Metabolism in Asthma, Isabelle Vachier, Pascal Chanez, Claude Chavis, Jean Bousquet, and Philippe GodardDesensitization in Aspirin-Induced Asthma, Donald D. Stevenson
