Geriatric Bioscience : The Link between Aging and Disease

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Geriatric Bioscience : The Link between Aging and Disease

Hamerman, David/ Butler, Robert N. (FRW)

ウェブストア価格 ¥10,835（本体¥9,850）
Johns Hopkins University Press（2008/01発売）
外貨定価 US$ 52.00
ポイント 98pt

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製本 Hardcover:ハードカバー版／ページ数 316 p.
言語 ENG
商品コード 9780801886928
DDC分類 618.97

Full Description

It is increasingly important for physicians who treat older persons, and for researchers on aging, to understand how molecular biology informs clinical expressions of aging and age-related conditions such as osteoporosis, diabetes, osteoarthritis, frailty, cancer, and dementia. Dr. David Hamerman translates basic scientific concepts into precepts of clinical practice and sheds light on the links among biology, natural aging, longevity, and disease. Exploring the connections between disease and the science behind it, Geriatric Bioscience addresses how mechanisms of inflammation, cytokine expression, and stress responses influence disease and how preventive gerontology in the practice of medicine could compress morbidity. Hamerman also discusses cutting-edge therapies such as cyclo-oxygenases, bisphosphonates, statins, cytokine inhibitors, and hormone therapies.
Examining the science of geriatrics and converting its concepts into clinical applications, this groundbreaking work provides clinicians and researchers with a solid foundation for a greater understanding of the diagnosis, treatment, and prevention of age-related diseases as well as recommendations for promoting healthy aging.

Foreword by Robert N. Butler
Preface
1. The Emergence and Future of Geriatrics
2. An Introduction to Concepts of Molecular Biology
3. Aging
I. Trends in the Aging of the Population
II. What Is Aging? Can We Distinguish betweenAging and Disease?
III. Mechanisms of Aging
IV. Longevity: Genetics of Extended Life Span or Risk for Adverse Events
4. Interrelations of Certain Aging-related Conditions
I. Cytokines, Inflammation, and Responses to Stress
II. Atherosclerosis: Risk Factors for Cardiovascular Disease
III. The Metabolic Syndrome and Type 2 Diabetes
IV. Osteoporosis
V. Osteoarthritis
VI. Frailty and Related Conditions: Anorexia, Sarcopenia, Exercise
VII. Cancer
VIII. Alzheimer Disease
5. Interactive Therapies Significant for an Aging Population
I. Cyclooxygenases
II. Statins
III. Bisphosphonates
IV. Thiazolidinediones and Peroxisome Proliferatoractivated Receptor
V. Cytokine Inhibitors as a Landmark for Newer Anti-inflammatory Therapies
VI. Hormonal Therapies
6. Preventive Gerontology
I. The Compression or Expansion of Morbidity?
II. Healthy Lifestyle Practices
III. "Successful Aging"
Epilogue
Glossary
References
Index