Full Description
Learn the facts behind the pharmacology and pharmacokinetics of controversial cannabis therapeutics
The Handbook of Cannabis Therapeutics: From Bench to Bedside sets aside the condemnation and hysteria of society's view of cannabis to concentrate on the medically sound aspects of cannabis therapeutics. The world's foremost experts provide a reasoned, thoroughly researched overview of the controversial subject of cannabis, from its history as a medicine through its latest therapeutic uses. The latest studies on the botany, history, biochemistry, pharmacology, toxicology, clinical use for various illnesses such as AIDS, epilepsy, and multiple sclerosis, and side effects of marijuana are all examined and discussed in depth.
This comprehensive resource is a compendium of articles from the Journal of Cannabis Therapeuticswith additional contemporary commentary. It presents startling research that explores and supports the medicinal value of cannabis use and its derivatives as a valid therapeutic resource for pain and inflammation, for several illnesses less responsive to other therapies, and even for certain veterinary uses. Cannabinoids such as nabilone, THC, levonantradol, ajulemic acid, dexanabinal, and others are extensively described, with a review of new indications for cannabinoid pharmaceuticals. The book is carefully referenced to encourage your examination of previous studies and provides tables and figures to enhance understanding of information.
The Handbook of Cannabis Therapeutics discusses:
the uses of cannabis in Arabic, Greek, Roman, and early English medicines
absorption rates
pharmacokinetics
pharmacodynamics
separate extracts versus the use of cannabis in its entirety
the therapeutic value of the endocannabinoid system
cannabinoids and newborn feeding
a comparison of smoking versus oral preparations
clinical research data on eating cannabis
therapeutic uses as appetite stimulant
treatments in obstetrics and gynecology
medicinal treatments used in Jamaica
the use of cannabis in the treatment of multiple sclerosis
the benefits versus the adverse side effects of cannabis use
The Handbook of Cannabis Therapeutics is a reference work certain to become crucial to physicians, psychologists, researchers, biochemists, graduate students, and interested members of the public.
Contents
About the Editors
Contributors
Foreword
Introduction (Franjo Grotenhermen)
PART I: HISTORICAL NOTES
Chapter 1. The Therapeutic Use of Cannabis sativa L. in Arabic Medicine (Indalecio Lozano)
Introduction
Materials and Methods
Results
Conclusion
Update
Chapter 2. Cognoscenti of Cannabis I: Jacques-Joseph Moreau (1804-1884) (Ethan B. Russo)
Chapter 3. Cognoscenti of Cannabis II: Simeon Seth on Cannabis (David Deakle)
Chapter 4. The Medical Use of Cannabis Among the Greeks and Romans (James L. Butrica)
Introduction
Absence of Mention
The Emergence of Cannabis
Appendix I: Passages Discussing Wild Cannabis Possibly Misunderstood As Discussing Domesticated Cannabis
Appendix II: Cannabis in Veterinary Medicine
Update
Chapter 5. A Homelie Herbe: Medicinal Cannabis in Early England (Vivienne Crawford)
Introduction
Cannabis History in England
The Modern Era
Update
Chapter 6. Future of Cannabis and Cannabinoids in Therapeutics (Ethan B. Russo)
Introduction
New Indications for Cannabinoid Pharmaceuticals
Cannabinoids and Neuroprotection
Spasmodic Disorders
Forbidden Territories
Update
PART II: PHARMACOLOGY AND PHARMACOKINETICS
Chapter 7. Clinical Pharmacokinetics of Cannabinoids (Franjo Grotenhermen)
Introduction
Pharmacokinetics of 9-THC
Absorption
Distribution
Metabolism
Course of Plasma Concentration of THC and Metabolites
Elimination
Time Effect Relationship
Pharmacokinetics of Other Cannabinoids
Metabolic Interactions
Conclusion
Chapter 8. Clinical Pharmacodynamics of Cannabinoids (Franjo Grotenhermen)
Introduction
Mechanism of Action
Cannabinoid Receptors
Endocannabinoids
Pharmacological Effects of THC
Toxicity
Psyche, Cognition and Behavior
Central Nervous System and Neurochemistry
Circulatory System
Some Other Organ Systems and Effects
Pharmacological Activity of THC Metabolites
Pharmacological Effects of Other Cannabinoids
Tolerance and Dependency
Therapeutic Uses
Hierarchy of Therapeutic Effects
Basic Research Stage
Drug Interactions
Conclusions
Update
Chapter 9. Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts? (John M. McPartland and Ethan B. Russo)
Introduction
Materials and Methods
Results and Discussion
Cannabinoids
Terpenoids
Flavonoids
Conclusions
Update
PART III: ENDOCANNABINOIDS AND CANNABINOID RECEPTORS
Chapter 10. The Endocannabinoid System: Can It Contribute to Cannabis Therapeutics? (Vincenzo Di Marzo)
The Endocannabinoid System
Endocannabinoid Pharmacology: More Than Meets the Eye
Levels of Endocannabinoids in Tissues: Physiology and Pathology
New Drugs from the Endocannabinoid System: Curative or Palliative?
Update
Chapter 11. Cannabinoids and Feeding: The Role of the Endogenous Cannabinoid System As a Trigger for Newborn Suckling (Ester Fride)
Interactions of the Endocannabinoids System with Hormones Regulating Food Intake
Endocannabinoids in Food Substances
Developmental Aspects of the Endocannabinoid-CB1 Receptor System
Blockade of CB1 Receptors in Newborn Mice
Mechanisms of the CB1 Receptor Blockade-Induced Growth-Stunting Effects
Conclusions
Update
PART IV: MEDICINAL USES
Chapter 12. Mariju
