基本説明
Provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases.
Full Description
This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis for this has begun to be studied in depth and fully understood. This compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances. The link between early development and the onset of many chronic diseases such as coronary heart disease, diabetes and osteoporosis, also raises important public health issues. Another fascinating theme in the book concerns evolutionary developmental biology and how the 'evo-devo' debate can cast light on these concepts. Clinicians and scientists alike will all learn a lot about this exciting and emerging field.
Contents
1. The developmental origins of health and disease: an overview; 2. The 'developmental origins' hypothesis: epidemiology; 3. The conceptual basis for the developmental origins of health and disease; 4. The periconceptional and embryonic period; 5. Epigenetic mechanisms; 6. A mitochondrial component of developmental programming; 7. Role of exposure to environmental chemicals in developmental origins of health and disease; 8. Maternal nutrition and fetal growth and development; 9. Placental mechanisms and developmental origins of health and disease; 10. Control of fetal metabolism: relevance to developmental origins of health and disease; 11. Lipid metabolism: relevance to developmental origins of health and disease; 12. Prenatal hypoxia: relevance to developmental origins of health and disease; 13. The fetal hypothalamic-pituitary-adrenal axis: relevance to developmental origins of health and disease;14. Perinatal influences on the endocrine and metabolic axes during childhood; 15. Developmental origins of health and disease: relevance of patterns of growth; 16. The developmental environment and the endocrine pancreas; 17. The develop; 28. The developmental environment and the origins of neurological disorders mental environment and insulin resistance; 18. The developmental environment and the development of obesity; 19. The developmental environment and its role in the metabolic syndrome; 20. Programming the cardiovascular system; 21. The role of vascular dysfunction in developmental; 22. The developmental environment and atherogenesis origins of health and disease: evidence from studies in man and animals; 23. The developmental environment, renal function and disease; 24. The developmental environment: effect on fluid and electrolyte homeostasis; 25. The developmental environment: effects on lung structure and function; 26. Developmental origins of asthma and related allergic disorders; 27. The developmental environment: Influences on subsequent cognitive function and behaviour; 28. The developmental environment and the origins of neurological disorders; 29. The developmental environment: clinical perspectives on effects on the musculoskeletal system; 30. The developmental environment: experimental perspectives on skeletal development; 31. The developmental environment and the early origins of cancer; 32. The developmental environment: implications for aging and lifespan; 33. Developmental origins of health and disease: implications for primary intervention for cardiovascular and metabolic disease; 34. Developmental origins of health and disease: public health perspectives; 35. Developmental origins of health and disease: implications for developing countries; 36. Developmental origins of health and disease: ethical and social considerations.
